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Literature summary extracted from

  • Kuper, H.; Beintema, J.J.
    The amino acid sequence of topi pancreatic ribonuclease (1976), Biochim. Biophys. Acta, 446, 337-344.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.6.1.18 RNA + H2O Damaliscus lunatus korrigum endonucleolytic cleavage to 3'-phosphomononucleotides and 3'-phosphooligonucleotides ending in Cp or Up with 2',3'-cyclic phosphate intermediates, e.g. tRNA, 18S and 28S rRNA, yeast RNA,4.5S RNA 3'-phosphomononucleotides + 3'-phosphooligonucleotides
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
4.6.1.18 Damaliscus lunatus korrigum
-
 topi, 2 forms: A and B differ in carbohydrate
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
4.6.1.18 glycoprotein 3 components, 2 of them are glycosylated Damaliscus lunatus korrigum

Purification (Commentary)

EC Number Purification (Comment) Organism
4.6.1.18 partial Damaliscus lunatus korrigum

Source Tissue

EC Number Source Tissue Comment Organism Textmining
4.6.1.18 pancreas
-
 Damaliscus lunatus korrigum
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.6.1.18 cyclic 2',3'-nucleoside monophosphate + H2O second step of hydrolysis is irreversible Damaliscus lunatus korrigum 3'-phosphomononucleotides
-
 ir
4.6.1.18 RNA + H2O endonucleolytic cleavage to 3'-phosphomononucleotides and 3'-phosphooligonucleotides ending in Cp or Up with 2',3'-cyclic phosphate intermediates, e.g. tRNA, 18S and 28S rRNA, yeast RNA,4.5S RNA Damaliscus lunatus korrigum 3'-phosphomononucleotides + 3'-phosphooligonucleotides
-
 ?
4.6.1.18 RNA + H2O first step of hydrolysis is reversible Damaliscus lunatus korrigum cyclic 2',3'-nucleoside monophosphate
-
 r