Literature summary extracted from

Yamada, T.; Nakazawa, Y.; Ukita, T.
Comparison of the primary structure of whale pancreatic ribonuclease with ribonuclease A (1974), J. Biochem., 75, 153-164.

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
4.6.1.18	iodoacetate	-	Cetacea

Natural Substrates/ Products (Substrates)

EC Number	Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
4.6.1.18	RNA + H2O	Cetacea	endonucleolytic cleavage to 3'-phosphomononucleotides and 3'-phosphooligonucleotides ending in Cp or Up with 2',3'-cyclic phosphate intermediates, e.g. tRNA, 18S and 28S rRNA, yeast RNA,4.5S RNA	3'-phosphomononucleotides + 3'-phosphooligonucleotides	-	?

Organism

EC Number	Organism	UniProt	Comment	Textmining
4.6.1.18	Cetacea	-	-	-

Purification (Commentary)

EC Number	Purification (Comment)	Organism
4.6.1.18	partial	Cetacea

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
4.6.1.18	pancreas	-	Cetacea	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
4.6.1.18	cyclic 2',3'-nucleoside monophosphate + H2O	second step of hydrolysis is irreversible	Cetacea	3'-phosphomononucleotides	-	ir
4.6.1.18	RNA + H2O	endonucleolytic cleavage to 3'-phosphomononucleotides and 3'-phosphooligonucleotides ending in Cp or Up with 2',3'-cyclic phosphate intermediates, e.g. tRNA, 18S and 28S rRNA, yeast RNA,4.5S RNA	Cetacea	3'-phosphomononucleotides + 3'-phosphooligonucleotides	-	?
4.6.1.18	RNA + H2O	first step of hydrolysis is reversible	Cetacea	cyclic 2',3'-nucleoside monophosphate	-	r

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)