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Literature summary extracted from

  • Becker, R.R.; Halbrook, J.L.; Hirs, C.H.W.
    Isolation and characterization of ovine ribonuclease A, B, and C from pancreatic secretion (1973), J. Biol. Chem., 248, 7826-7832.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.6.1.18 RNA + H2O Ovis aries endonucleolytic cleavage to 3'-phosphomononucleotides and 3'-phosphooligonucleotides ending in Cp or Up with 2',3'-cyclic phosphate intermediates, e.g. tRNA, 18S and 28S rRNA, yeast RNA,4.5S RNA 3'-phosphomononucleotides + 3'-phosphooligonucleotides
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
4.6.1.18 Ovis aries
-
 3 forms: A, B, C: same amino acid composition, B and C: glycoproteins, A: not
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
4.6.1.18 glycoprotein B-from contains 2 N-acetylglucosamine and 6 mannose residues, C-form contains in addition galactose, and fucose Ovis aries
4.6.1.18 glycoprotein 3 distinct forms: A, B, C, B and C: glycoproteins, A: not Ovis aries

Purification (Commentary)

EC Number Purification (Comment) Organism
4.6.1.18 partial Ovis aries

Source Tissue

EC Number Source Tissue Comment Organism Textmining
4.6.1.18 pancreas
-
 Ovis aries
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.6.1.18 cyclic 2',3'-cytidine monophosphate + H2O
-
 Ovis aries 3'-CMP
-
 ir
4.6.1.18 cyclic 2',3'-nucleoside monophosphate + H2O second step of hydrolysis is irreversible Ovis aries 3'-phosphomononucleotides
-
 ir
4.6.1.18 RNA + H2O endonucleolytic cleavage to 3'-phosphomononucleotides and 3'-phosphooligonucleotides ending in Cp or Up with 2',3'-cyclic phosphate intermediates, e.g. tRNA, 18S and 28S rRNA, yeast RNA,4.5S RNA Ovis aries 3'-phosphomononucleotides + 3'-phosphooligonucleotides
-
 ?
4.6.1.18 RNA + H2O first step of hydrolysis is reversible Ovis aries cyclic 2',3'-nucleoside monophosphate
-
 r