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Literature summary extracted from

  • Dalaly, B.K.; Eitenmiller, R.R.; Friend, B.A.; Shahani, K.M.
    Human milk ribonuclease (1980), Biochim. Biophys. Acta, 615, 381-391.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
4.6.1.18 KCl
-
 Homo sapiens
4.6.1.18 NaCl
-
 Homo sapiens
4.6.1.18 Sodium citrate
-
 Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.6.1.18 CaCl2
-
 Homo sapiens
4.6.1.18 CuSO4
-
 Homo sapiens
4.6.1.18 FeSO4
-
 Homo sapiens
4.6.1.18 Mg2+
-
 Homo sapiens
4.6.1.18 ZnSO4
-
 Homo sapiens

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
4.6.1.18 K+ increases activity Homo sapiens
4.6.1.18 Na+ increases activity Homo sapiens

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
4.6.1.18 14020
-
 milk, sedimentation ultracentrifugation Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.6.1.18 RNA + H2O Homo sapiens endonucleolytic cleavage to 3'-phosphomononucleotides and 3'-phosphooligonucleotides ending in Cp or Up with 2',3'-cyclic phosphate intermediates, e.g. tRNA, 18S and 28S rRNA, yeast RNA,4.5S RNA 3'-phosphomononucleotides + 3'-phosphooligonucleotides
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
4.6.1.18 Homo sapiens
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
4.6.1.18
-
 Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
4.6.1.18 liver
-
 Homo sapiens
-
4.6.1.18 milk
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.6.1.18 cyclic 2',3'-nucleoside monophosphate + H2O second step of hydrolysis is irreversible Homo sapiens 3'-phosphomononucleotides
-
 ir
4.6.1.18 poly (C) + H2O
-
 Homo sapiens 3'-CMP + 3'-phosphooligonucleotides
-
 ?
4.6.1.18 poly U + H2O
-
 Homo sapiens 3'-UMP + 3'-oligonucleotides
-
 ?
4.6.1.18 RNA + H2O not: single-stranded homopolyribonucleotides other than poly(C) and poly(U) Homo sapiens 3'-phosphomononucleotides + 3'-phosphooligonucleotides
-
 ?
4.6.1.18 RNA + H2O endonucleolytic cleavage to 3'-phosphomononucleotides and 3'-phosphooligonucleotides ending in Cp or Up with 2',3'-cyclic phosphate intermediates, e.g. tRNA, 18S and 28S rRNA, yeast RNA,4.5S RNA Homo sapiens 3'-phosphomononucleotides + 3'-phosphooligonucleotides
-
 ?
4.6.1.18 RNA + H2O first step of hydrolysis is reversible Homo sapiens cyclic 2',3'-nucleoside monophosphate
-
 r

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
4.6.1.18 60
-
-
 Homo sapiens

Temperature Range [°C]

EC Number Temperature Minimum [°C] Temperature Maximum [°C] Comment Organism
4.6.1.18 15 70 25°C: about 5% of activity maximum, 70°C: about 45% of activity maximum Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
4.6.1.18 7.7
-
-
 Homo sapiens

pH Range

EC Number pH Minimum pH Maximum Comment Organism
4.6.1.18 3 9 pH 3.0: about 10% of activity maximum, pH 9.0: about 5% of activity maximum Homo sapiens