EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
3.1.26.4 | KCl | half-maximal inhibition at 150 mM | Homo sapiens |
EC Number | Metals/Ions | Comment | Organism | Structure |
---|---|---|---|---|
3.1.26.4 | Co2+ | divalent metal ion required. Maximal activity is obtained with 10 mM Mg2+, 5 mM Co2+ or 0.5 mM Mn2+ | Homo sapiens | |
3.1.26.4 | KCl | activity increases with concentrations up to 50 mM | Homo sapiens | |
3.1.26.4 | Mg2+ | divalent metal ion required. Maximal activity is obtained with 10 mM Mg2+, 5 mM Co2+ or 0.5 mM Mn2+ | Homo sapiens | |
3.1.26.4 | Mn2+ | divalent metal ion required. Maximal activity is obtained with 10 mM Mg2+, 5 mM Co2+ or 0.5 mM Mn2+ | Homo sapiens |
EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|---|
3.1.26.4 | 89000 | - |
sucrose density gradient centrifugation | Homo sapiens |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.1.26.4 | RNA-DNA hybrid + H2O | Homo sapiens | the enzyme may play a role in ribonucleotide excision from genomic DNA during replication | ? | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
3.1.26.4 | Homo sapiens | - |
- |
- |
EC Number | Purification (Comment) | Organism |
---|---|---|
3.1.26.4 | RNase H1 | Homo sapiens |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
3.1.26.4 | K-562 cell | K562 | Homo sapiens | - |
EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|---|
3.1.26.4 | 22 | - |
- |
Homo sapiens |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.1.26.4 | additional information | the enzyme lacks double-stranded and single-stranded RNase and DNase activities. No hydrolysis of the DNA moiety of the RNA/DNA heteroduplex | Homo sapiens | ? | - |
? | |
3.1.26.4 | RNA-DNA hybrid + H2O | the enzyme can hydrolyze a DNA*RNA*DNA/DNA heteroduplex that contains a single ribonucleotide | Homo sapiens | ribonucleotide 5'-phosphomonoester | - |
? | |
3.1.26.4 | RNA-DNA hybrid + H2O | poly(rUdA) | Homo sapiens | ribonucleotide 5'-phosphomonoester | - |
? | |
3.1.26.4 | RNA-DNA hybrid + H2O | poly(rAdT) | Homo sapiens | ribonucleotide 5'-phosphomonoester | - |
? | |
3.1.26.4 | RNA-DNA hybrid + H2O | the enzyme may play a role in ribonucleotide excision from genomic DNA during replication | Homo sapiens | ? | - |
? |
EC Number | Subunits | Comment | Organism |
---|---|---|---|
3.1.26.4 | ? | - |
Homo sapiens |
EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|---|
3.1.26.4 | 8 | 8.5 | in presence of 10 mM Mg2+ | Homo sapiens |