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Literature summary extracted from

  • Talesa, V.; Uotila, L.; Koivusalo, M.; Principato, G.; Giovannini, E.; Rosi, G.
    Demonstration of glyoxalase II in rat liver mitochondria. Partial purification and occurrence in multiple forms (1988), Biochim. Biophys. Acta, 955, 103-110.
    View publication on PubMed

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.1.2.6 0.044
-
 S-(beta-ethoxy-alpha-D-hydroxybutyryl)glutathione cytosolic enzyme Rattus norvegicus
3.1.2.6 0.05
-
 S-(beta-ethoxy-alpha-D-hydroxybutyryl)glutathione mitochondrial enzyme Rattus norvegicus
3.1.2.6 0.16
-
 S-succinylglutathione mitochondrial enzyme Rattus norvegicus
3.1.2.6 0.213
-
 S-formylglutathione cytosolic enzyme Rattus norvegicus
3.1.2.6 0.214
-
 S-propionylglutathione cytosolic enzyme Rattus norvegicus
3.1.2.6 0.242
-
 S-propionylglutathione mitochondrial enzyme Rattus norvegicus
3.1.2.6 0.325
-
 S-succinylglutathione cytosolic enzyme Rattus norvegicus
3.1.2.6 0.378
-
 S-propionylglutathione mitochondrial enzyme Rattus norvegicus
3.1.2.6 0.433
-
 S-D-lactoylglutathione cytosolic enzyme Rattus norvegicus
3.1.2.6 0.44
-
 S-D-lactoylglutathione mitochondrial enzyme Rattus norvegicus
3.1.2.6 0.568
-
 S-acetylglutathione cytosolic enzyme Rattus norvegicus
3.1.2.6 0.662
-
 S-acetylglutathione mitochondrial enzyme Rattus norvegicus
3.1.2.6 0.703
-
 S-(beta-ethoxy-alpha-D-hydroxybutyryl)glutathione mitochondrial enzyme Rattus norvegicus
3.1.2.6 0.841
-
 S-Acetoacetylglutathione cytosolic enzyme Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.1.2.6 cytosol
-
 Rattus norvegicus 5829
-
3.1.2.6 mitochondrion 10-15% of the total glyoxalase II activity in liver. 56% of the activity resides in the matrix, 19% in the intermembrane space. 3 isoforms are exclusively mitochondrial Rattus norvegicus 5739
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.1.2.6 21000
-
-
 Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
3.1.2.6 Rattus norvegicus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.1.2.6 partial, multiple forms Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.2.6 liver
-
 Rattus norvegicus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
3.1.2.6 112
-
-
 Rattus norvegicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.2.6 lactoylglutathione + H2O
-
 Rattus norvegicus D-lactate + glutathione
-
 ?
3.1.2.6 S-(beta-ethoxy-alpha-D-hydroxybutyryl)glutathione + H2O
-
 Rattus norvegicus beta-ethoxy-alpha-D-hydroxybutyrate + glutathione
-
 ?
3.1.2.6 S-acetoacetylglutathione + H2O
-
 Rattus norvegicus acetoacetate + glutathione
-
 ?
3.1.2.6 S-acetylglutathione + H2O
-
 Rattus norvegicus acetate + glutathione
-
 ?
3.1.2.6 S-D-lactoylglutathione + H2O
-
 Rattus norvegicus D-lactate + glutathione
-
 ?
3.1.2.6 S-formylglutathione + H2O
-
 Rattus norvegicus formate + glutathione
-
 ?
3.1.2.6 S-propionylglutathione + H2O
-
 Rattus norvegicus propionate + glutathione
-
 ?
3.1.2.6 S-succinylglutathione + H2O
-
 Rattus norvegicus succinate + glutathione
-
 ?