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Literature summary extracted from

  • Korner, C.G.; Wormington, M.; Muckenthaler, M.; Schneider, S.; Dehlin, E.; Wahle, E.
    The deadenylating nuclease (DAN) is involved in poly(A) tail removal during the meiotic maturation of Xenopus oocytes (1998), EMBO J., 17, 5427-5437.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.1.13.4 CH3COOK absolute required in absence of spermidine Bos taurus
3.1.13.4 CH3COOK absolute required in absence of spermidine Xenopus sp.
3.1.13.4 spermidine absolute required in absence of salt Bos taurus
3.1.13.4 spermidine absolute required in absence of salt Xenopus sp.

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.1.13.4 expression in Escherichia coli Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.13.4 CH3COOK inhibits in presence of spermidine Bos taurus
3.1.13.4 CH3COOK
-
 Homo sapiens
3.1.13.4 CH3COOK inhibits in presence of spermidine Xenopus sp.
3.1.13.4 K3PO4 inhibits in presence of spermidine Bos taurus
3.1.13.4 K3PO4
-
 Homo sapiens
3.1.13.4 K3PO4 inhibits in presence of spermidine Xenopus sp.
3.1.13.4 poly(A)-binding protein PAB 1 inhibits; phased poly(A) shortening Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.1.13.4 cytoplasm
-
 Homo sapiens 5737
-
3.1.13.4 nucleus
-
 Bos taurus 5634
-
3.1.13.4 nucleus
-
 Homo sapiens 5634
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.1.13.4 K3PO4 absolute required in absence of spermidine Bos taurus
3.1.13.4 K3PO4 absolute required in absence of spermidine Xenopus sp.

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.1.13.4 62000 74000
-
 Xenopus sp.
3.1.13.4 73500
-
 amino acid analysis Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.13.4 poly(A) RNA + H2O Bos taurus
-
 5'-AMP + ?
-
 ?
3.1.13.4 poly(A) RNA + H2O Xenopus sp.
-
 5'-AMP + ?
-
 ?
3.1.13.4 poly(A) RNA + H2O Homo sapiens
-
 5'-AMP + ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.13.4 Bos taurus
-
-
-
3.1.13.4 Homo sapiens O95453
-
-
3.1.13.4 Xenopus sp.
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.1.13.4
-
 Xenopus sp.
3.1.13.4 of the recombinant protein Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.13.4 oocyte
-
 Homo sapiens
-
3.1.13.4 pancreas
-
 Bos taurus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.13.4 poly(A) RNA + H2O
-
 Bos taurus 5'-AMP + ?
-
 ?
3.1.13.4 poly(A) RNA + H2O
-
 Xenopus sp. 5'-AMP + ?
-
 ?
3.1.13.4 poly(A) RNA + H2O
-
 Homo sapiens 5'-AMP + ?
-
 ?
3.1.13.4 poly(A)-mRNA + H2O
-
 Bos taurus 5'-AMP
-
 ?
3.1.13.4 poly(A)-mRNA + H2O DAN involved in oocyte maturation Xenopus sp. 5'-AMP
-
 ?
3.1.13.4 poly(A)-mRNA + H2O DAN involved in oocyte maturation Homo sapiens 5'-AMP
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.13.4 More
-
 Bos taurus
3.1.13.4 More similar enzyme: DAN: deanylating nuclease Homo sapiens