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Literature summary extracted from

  • Cannistraro, V.J.; Kennell, D.
    The reaction mechanism of ribonuclease II and its interaction with nucleic acid secondary structures (1999), Biochim. Biophys. Acta, 1433, 170-187.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.13.1 DNA stem-loop structure free 3'- and 5'-arms needed for potent inhibition, weaker stem-loops are better inhibitors than their counterpart with a strong duplex Escherichia coli
3.1.13.1 mixed RNA-DNA oligonucleotides
-
 Escherichia coli
3.1.13.1 SDS complete inhibition 10 s after addition of SDS Escherichia coli
3.1.13.1 ss DNA oligonucleotides competitive inhibition, potent inhibitors have a poly(dC)-chain length of 23-29 Escherichia coli

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.13.1 ss RNA + H2O Escherichia coli
-
 5'-phosphomononucleotides
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.13.1 Escherichia coli
-
-
-

Reaction

EC Number Reaction Comment Organism Reaction ID
3.1.13.1 Exonucleolytic cleavage in the 3'- to 5'- direction to yield nucleoside 5'-phosphates acts in a processive manner Escherichia coli
a

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.13.1 additional information DNA oligomers with stem-loop structures are not hydrolyzed Escherichia coli ?
-
 ?
3.1.13.1 poly(C) + H2O
-
 Escherichia coli 5'-CMP + oligonucleotide
-
 ?
3.1.13.1 ss RNA + H2O
-
 Escherichia coli 5'-phosphomononucleotides
-
 ?