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Literature summary extracted from
- Bacterial deoxyribonucleases (1971), The Enzymes, 3rd Ed. (Boyer, P. D. , ed. ), 4, 251-270.
No PubMed abstract available
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.1.21.1 | RNA | enhanced activity by pretreatment with ribonuclease, variety of RNA's including tRNA | Escherichia coli |  |
Metals/Ions
| EC Number | Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.1.11.5 | Mg2+ | - |
Escherichia coli | |
| 3.1.11.5 | Mn2+ | - |
Escherichia coli | |
| 3.1.21.1 | Co2+ | absolute requirement for Mn2+ or Mg2+ | Escherichia coli | |
| 3.1.21.1 | Mg2+ | absolute requirement for Mg2+ or Mn2+ | Escherichia coli | |
| 3.1.21.1 | Mn2+ | - |
Escherichia coli | |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.1.11.3 | double-stranded DNA + H2O | Escherichia coli | - |
single-stranded DNA + 5'-phospho-2'-deoxynucleotides | - |
? | |
| 3.1.11.3 | double-stranded DNA + H2O | Lambdavirus lambda | - |
single-stranded DNA + 5'-phospho-2'-deoxynucleotides | - |
? | |
| 3.1.21.1 | double-stranded DNA + H2O | Escherichia coli | cleaves both strands of a double helix at or near the same level, about 400 nucleotides removed at each endonucleolytic scission, causes a "shattering" at the point of cleavage, leading to the libration of small oligonucleotides by an exonucleolytic mode of attack | 5'-phosphooligonucleotides + ? | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.1.11.3 | Escherichia coli | - |
Escherichia coli infected with phage lambda only | - |
| 3.1.11.3 | Lambdavirus lambda | - |
- |
- |
| 3.1.11.5 | Escherichia coli | - |
- |
- |
| 3.1.21.1 | Escherichia coli | - |
- |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 3.1.21.1 | cell culture | - |
Escherichia coli | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.1.11.3 | double-stranded DNA + H2O | - |
Escherichia coli | single-stranded DNA + 5'-phospho-2'-deoxynucleotides | - |
? | |
| 3.1.11.3 | double-stranded DNA + H2O | - |
Lambdavirus lambda | single-stranded DNA + 5'-phospho-2'-deoxynucleotides | - |
? | |
| 3.1.11.3 | double-stranded DNA + H2O | exonucleolytic cleavage in the 5'- to 3'-direction to yield 5'-phosphomononucleotides | Escherichia coli | single-stranded DNA + 5'-phospho-2'-deoxynucleotides | - |
? | |
| 3.1.11.3 | double-stranded DNA + H2O | exonucleolytic cleavage in the 5'- to 3'-direction to yield 5'-phosphomononucleotides | Lambdavirus lambda | single-stranded DNA + 5'-phospho-2'-deoxynucleotides | - |
? | |
| 3.1.11.3 | double-stranded DNA + H2O | possess "red" recombination system | Escherichia coli | single-stranded DNA + 5'-phospho-2'-deoxynucleotides | - |
? | |
| 3.1.11.3 | double-stranded DNA + H2O | possess "red" recombination system | Lambdavirus lambda | single-stranded DNA + 5'-phospho-2'-deoxynucleotides | - |
? | |
| 3.1.11.3 | double-stranded DNA + H2O | shows strong preference for termini bearing 5'-phosphoryl groups | Escherichia coli | single-stranded DNA + 5'-phospho-2'-deoxynucleotides | - |
? | |
| 3.1.11.3 | double-stranded DNA + H2O | shows strong preference for termini bearing 5'-phosphoryl groups | Lambdavirus lambda | single-stranded DNA + 5'-phospho-2'-deoxynucleotides | - |
? | |
| 3.1.11.3 | double-stranded DNA + H2O | no attack at single-stranded breaks within DNA-duplex | Escherichia coli | single-stranded DNA + 5'-phospho-2'-deoxynucleotides | - |
? | |
| 3.1.11.3 | double-stranded DNA + H2O | no attack at single-stranded breaks within DNA-duplex | Lambdavirus lambda | single-stranded DNA + 5'-phospho-2'-deoxynucleotides | - |
? | |
| 3.1.11.3 | double-stranded DNA + H2O | degrades double-stranded native DNA | Escherichia coli | single-stranded DNA + 5'-phospho-2'-deoxynucleotides | - |
? | |
| 3.1.11.3 | double-stranded DNA + H2O | degrades double-stranded native DNA | Lambdavirus lambda | single-stranded DNA + 5'-phospho-2'-deoxynucleotides | - |
? | |
| 3.1.11.3 | oligonucleotides + H2O | strong preference for relatively short chain oligonucleotides | Escherichia coli | 5'-phosphomononucleotides | - |
? | |
| 3.1.11.3 | oligonucleotides + H2O | strong preference for relatively short chain oligonucleotides | Lambdavirus lambda | 5'-phosphomononucleotides | - |
? | |
| 3.1.11.5 | double-stranded DNA + H2O | acts on native, heat-denatured and glucosylated DNA | Escherichia coli | single-stranded DNA fragments | - |
? | |
| 3.1.11.5 | double-stranded DNA + H2O | ATP dependent double-stranded DNA exonuclease | Escherichia coli | single-stranded DNA fragments | - |
? | |
| 3.1.21.1 | DNA + H2O | degrades native DNA 7fold faster than denatured DNA | Escherichia coli | 5'-phosphooligonucleotides + ? | products have an avarage chain length of 7 residues | ? | |
| 3.1.21.1 | double-stranded DNA + H2O | cleaves both strands of a double helix at or near the same level, about 400 nucleotides removed at each endonucleolytic scission, causes a "shattering" at the point of cleavage, leading to the libration of small oligonucleotides by an exonucleolytic mode of attack | Escherichia coli | 5'-phosphooligonucleotides + ? | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 3.1.11.3 | phage lambda-induced exonuclease | - |
Lambdavirus lambda |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 3.1.21.1 | 7.5 | 8.5 | - |
Escherichia coli |
pH Range
| EC Number | pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|---|
| 3.1.11.5 | 7.5 | 9.5 | - |
Escherichia coli |
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