BRENDA - Enzyme Database

Phospholipase A2 activity on mixed lipid monolayers: Activation of phospholipase A2 from porcine pancreas and Crotalus adamanteus by anionic and neutral amphophiles

Hendrickson, H.S.; Trygstad, W.M.; Loftness, T.L.; Sailer, S.L.; Arch. Biochem. Biophys. 212, 508-514 (1981)

Data extracted from this reference:

Activating Compound
EC Number
Activating Compound
Commentary
Organism
Structure
3.1.1.4
3,5-Dibromosalicylate
enhanced enzyme penetration, activation above the normal cutoff pressure of PLA2
Crotalus adamanteus
3.1.1.4
3,5-Dibromosalicylate
enhanced enzyme penetration, activation above the normal cutoff pressure of PLA2
Sus scrofa
3.1.1.4
3,5-diiodosalicylate
enhanced enzyme penetration, activation above the normal cutoff pressure of PLA2
Crotalus adamanteus
3.1.1.4
3,5-diiodosalicylate
enhanced enzyme penetration, activation above the normal cutoff pressure of PLA2
Sus scrofa
3.1.1.4
Acetyl salicylate
enhanced enzyme penetration, activation above the normal cutoff pressure of PLA2
Crotalus adamanteus
3.1.1.4
Acetyl salicylate
enhanced enzyme penetration, activation above the normal cutoff pressure of PLA2
Sus scrofa
3.1.1.4
Dicetyl phosphate
enhanced enzyme penetration, activation above the normal cutoff pressure of PLA2
Crotalus adamanteus
3.1.1.4
Dicetyl phosphate
enhanced enzyme penetration, activation above the normal cutoff pressure of PLA2
Sus scrofa
3.1.1.4
salicylic acid
enhanced enzyme penetration, activation above the normal cutoff pressure of PLA2
Crotalus adamanteus
3.1.1.4
salicylic acid
enhanced enzyme penetration, activation above the normal cutoff pressure of PLA2
Sus scrofa
Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
3.1.1.4
1,2-Didecanoin
inhibition below the normal cutoff pressure of PLA2
Crotalus adamanteus
3.1.1.4
1,2-Didecanoin
inhibition below the normal cutoff pressure of PLA2
Sus scrofa
3.1.1.4
3,5-Dibromosalicylate
inhibition below the normal cutoff pressure of PLA2
Crotalus adamanteus
3.1.1.4
3,5-Dibromosalicylate
inhibition below the normal cutoff pressure of PLA2
Sus scrofa
3.1.1.4
3,5-diiodosalicylate
inhibition below the normal cutoff pressure of PLA2
Crotalus adamanteus
3.1.1.4
3,5-diiodosalicylate
inhibition below the normal cutoff pressure of PLA2
Sus scrofa
3.1.1.4
Acetyl salicylate
inhibition below the normal cutoff pressure of PLA2
Crotalus adamanteus
3.1.1.4
Acetyl salicylate
inhibition below the normal cutoff pressure of PLA2
Sus scrofa
3.1.1.4
Dicetyl phosphate
inhibition below the normal cutoff pressure of PLA2
Crotalus adamanteus
3.1.1.4
Dicetyl phosphate
inhibition below the normal cutoff pressure of PLA2
Sus scrofa
3.1.1.4
N-dodecyl-N,N-dimethyl-3-aminopropanesulfonate
-
Sus scrofa
3.1.1.4
N-tetradecyl-N,N-dimethyl-3-aminopropanesulfonate
-
Sus scrofa
3.1.1.4
salicylic acid
inhibition below the normal cutoff pressure of PLA2
Crotalus adamanteus
3.1.1.4
salicylic acid
inhibition below the normal cutoff pressure of PLA2
Sus scrofa
Natural Substrates/ Products (Substrates)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
3.1.1.4
phosphatidylcholine + H2O
Sus scrofa
-
diacylglycerol + phosphorylcholine
-
-
?
3.1.1.4
phosphatidylcholine + H2O
Crotalus adamanteus
-
diacylglycerol + phosphorylcholine
-
-
?
3.1.1.4
phospholipids + H2O
Sus scrofa
-
?
-
-
?
3.1.1.4
phospholipids + H2O
Crotalus adamanteus
-
?
-
-
?
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
3.1.1.4
Crotalus adamanteus
-
-
-
3.1.1.4
Sus scrofa
-
-
-
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
3.1.1.4
pancreas
-
Sus scrofa
-
3.1.1.4
venom
-
Crotalus adamanteus
-
Storage Stability
EC Number
Storage Stability
Organism
3.1.1.4
4°C, 1 mg PLA2 per ml
Sus scrofa
3.1.1.4
4°C, 1 mg PLA2 per ml
Crotalus adamanteus
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
3.1.1.4
1,2-didecanoyl-sn-glycero-3-phosphocholine + H2O
-
133911
Sus scrofa
1-decanoyl-sn-glycero-3-phosphocholine + decanoate
-
133911
Sus scrofa
?
3.1.1.4
1,2-didecanoyl-sn-glycero-3-phosphocholine + H2O
-
133911
Crotalus adamanteus
1-decanoyl-sn-glycero-3-phosphocholine + decanoate
-
133911
Crotalus adamanteus
?
3.1.1.4
phosphatidic acid + H2O
-
133911
Sus scrofa
1-acylglycerophosphate + fatty acid
-
133911
Sus scrofa
?
3.1.1.4
phosphatidic acid + H2O
-
133911
Crotalus adamanteus
1-acylglycerophosphate + fatty acid
-
133911
Crotalus adamanteus
?
3.1.1.4
phosphatidylcholine + H2O
-
133911
Sus scrofa
1-acylglycerophosphocholine + fatty acid
-
133911
Sus scrofa
?
3.1.1.4
phosphatidylcholine + H2O
-
133911
Crotalus adamanteus
1-acylglycerophosphocholine + fatty acid
-
133911
Crotalus adamanteus
?
3.1.1.4
phosphatidylcholine + H2O
-
133911
Sus scrofa
diacylglycerol + phosphorylcholine
-
-
-
?
3.1.1.4
phosphatidylcholine + H2O
-
133911
Crotalus adamanteus
diacylglycerol + phosphorylcholine
-
-
-
?
3.1.1.4
phosphatidylglycerol + H2O
-
133911
Sus scrofa
1-acylglycerol + fatty acid
-
133911
Sus scrofa
?
3.1.1.4
phosphatidylglycerol + H2O
-
133911
Crotalus adamanteus
1-acylglycerol + fatty acid
-
133911
Crotalus adamanteus
?
3.1.1.4
phospholipids + H2O
-
133911
Sus scrofa
?
-
-
-
?
3.1.1.4
phospholipids + H2O
-
133911
Crotalus adamanteus
?
-
-
-
?
Activating Compound (protein specific)
EC Number
Activating Compound
Commentary
Organism
Structure
3.1.1.4
3,5-Dibromosalicylate
enhanced enzyme penetration, activation above the normal cutoff pressure of PLA2
Crotalus adamanteus
3.1.1.4
3,5-Dibromosalicylate
enhanced enzyme penetration, activation above the normal cutoff pressure of PLA2
Sus scrofa
3.1.1.4
3,5-diiodosalicylate
enhanced enzyme penetration, activation above the normal cutoff pressure of PLA2
Crotalus adamanteus
3.1.1.4
3,5-diiodosalicylate
enhanced enzyme penetration, activation above the normal cutoff pressure of PLA2
Sus scrofa
3.1.1.4
Acetyl salicylate
enhanced enzyme penetration, activation above the normal cutoff pressure of PLA2
Crotalus adamanteus
3.1.1.4
Acetyl salicylate
enhanced enzyme penetration, activation above the normal cutoff pressure of PLA2
Sus scrofa
3.1.1.4
Dicetyl phosphate
enhanced enzyme penetration, activation above the normal cutoff pressure of PLA2
Crotalus adamanteus
3.1.1.4
Dicetyl phosphate
enhanced enzyme penetration, activation above the normal cutoff pressure of PLA2
Sus scrofa
3.1.1.4
salicylic acid
enhanced enzyme penetration, activation above the normal cutoff pressure of PLA2
Crotalus adamanteus
3.1.1.4
salicylic acid
enhanced enzyme penetration, activation above the normal cutoff pressure of PLA2
Sus scrofa
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
3.1.1.4
1,2-Didecanoin
inhibition below the normal cutoff pressure of PLA2
Crotalus adamanteus
3.1.1.4
1,2-Didecanoin
inhibition below the normal cutoff pressure of PLA2
Sus scrofa
3.1.1.4
3,5-Dibromosalicylate
inhibition below the normal cutoff pressure of PLA2
Crotalus adamanteus
3.1.1.4
3,5-Dibromosalicylate
inhibition below the normal cutoff pressure of PLA2
Sus scrofa
3.1.1.4
3,5-diiodosalicylate
inhibition below the normal cutoff pressure of PLA2
Crotalus adamanteus
3.1.1.4
3,5-diiodosalicylate
inhibition below the normal cutoff pressure of PLA2
Sus scrofa
3.1.1.4
Acetyl salicylate
inhibition below the normal cutoff pressure of PLA2
Crotalus adamanteus
3.1.1.4
Acetyl salicylate
inhibition below the normal cutoff pressure of PLA2
Sus scrofa
3.1.1.4
Dicetyl phosphate
inhibition below the normal cutoff pressure of PLA2
Crotalus adamanteus
3.1.1.4
Dicetyl phosphate
inhibition below the normal cutoff pressure of PLA2
Sus scrofa
3.1.1.4
N-dodecyl-N,N-dimethyl-3-aminopropanesulfonate
-
Sus scrofa
3.1.1.4
N-tetradecyl-N,N-dimethyl-3-aminopropanesulfonate
-
Sus scrofa
3.1.1.4
salicylic acid
inhibition below the normal cutoff pressure of PLA2
Crotalus adamanteus
3.1.1.4
salicylic acid
inhibition below the normal cutoff pressure of PLA2
Sus scrofa
Natural Substrates/ Products (Substrates) (protein specific)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
3.1.1.4
phosphatidylcholine + H2O
Sus scrofa
-
diacylglycerol + phosphorylcholine
-
-
?
3.1.1.4
phosphatidylcholine + H2O
Crotalus adamanteus
-
diacylglycerol + phosphorylcholine
-
-
?
3.1.1.4
phospholipids + H2O
Sus scrofa
-
?
-
-
?
3.1.1.4
phospholipids + H2O
Crotalus adamanteus
-
?
-
-
?
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
3.1.1.4
pancreas
-
Sus scrofa
-
3.1.1.4
venom
-
Crotalus adamanteus
-
Storage Stability (protein specific)
EC Number
Storage Stability
Organism
3.1.1.4
4°C, 1 mg PLA2 per ml
Sus scrofa
3.1.1.4
4°C, 1 mg PLA2 per ml
Crotalus adamanteus
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
3.1.1.4
1,2-didecanoyl-sn-glycero-3-phosphocholine + H2O
-
133911
Sus scrofa
1-decanoyl-sn-glycero-3-phosphocholine + decanoate
-
133911
Sus scrofa
?
3.1.1.4
1,2-didecanoyl-sn-glycero-3-phosphocholine + H2O
-
133911
Crotalus adamanteus
1-decanoyl-sn-glycero-3-phosphocholine + decanoate
-
133911
Crotalus adamanteus
?
3.1.1.4
phosphatidic acid + H2O
-
133911
Sus scrofa
1-acylglycerophosphate + fatty acid
-
133911
Sus scrofa
?
3.1.1.4
phosphatidic acid + H2O
-
133911
Crotalus adamanteus
1-acylglycerophosphate + fatty acid
-
133911
Crotalus adamanteus
?
3.1.1.4
phosphatidylcholine + H2O
-
133911
Sus scrofa
1-acylglycerophosphocholine + fatty acid
-
133911
Sus scrofa
?
3.1.1.4
phosphatidylcholine + H2O
-
133911
Crotalus adamanteus
1-acylglycerophosphocholine + fatty acid
-
133911
Crotalus adamanteus
?
3.1.1.4
phosphatidylcholine + H2O
-
133911
Sus scrofa
diacylglycerol + phosphorylcholine
-
-
-
?
3.1.1.4
phosphatidylcholine + H2O
-
133911
Crotalus adamanteus
diacylglycerol + phosphorylcholine
-
-
-
?
3.1.1.4
phosphatidylglycerol + H2O
-
133911
Sus scrofa
1-acylglycerol + fatty acid
-
133911
Sus scrofa
?
3.1.1.4
phosphatidylglycerol + H2O
-
133911
Crotalus adamanteus
1-acylglycerol + fatty acid
-
133911
Crotalus adamanteus
?
3.1.1.4
phospholipids + H2O
-
133911
Sus scrofa
?
-
-
-
?
3.1.1.4
phospholipids + H2O
-
133911
Crotalus adamanteus
?
-
-
-
?