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Literature summary extracted from

  • Takayama, K.; Kudo, I.; Kim, D.K.; Nagata, K.; Nozawa, Y.; Inoue, K.
    Purification and characterization of human platelet phospholipase A2 which preferentially hydrolyzes an arachidonoyl residue (1991), FEBS Lett., 282, 326-330.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.1.4 EGTA
-
 Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.1.1.4 cytoplasm
-
 Homo sapiens 5737
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.1.1.4 Ca2+
-
 Homo sapiens

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.1.1.4 90000
-
 SDS-PAGE Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.1.4 phospholipids + H2O Homo sapiens release of arachidonic acid: biosynthesis of leucotrienes, thromboxans and prostaglandins ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.1.4 Homo sapiens
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.1.1.4 column chromatography steps, 11700fold Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.1.4 platelet
-
 Homo sapiens
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
3.1.1.4 0.259
-
 substrate: 1-acyl-2-arachidonoyl-glycerophosphocholine Homo sapiens

Storage Stability

EC Number Storage Stability Organism
3.1.1.4 -80°C Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.1.4 1-acyl-2-arachidonoyl-glycerophosphocholine + H2O
-
 Homo sapiens 1-acyl-glycerophosphocholine + arachidonic acid
-
 ?
3.1.1.4 1-acyl-2-arachidonoyl-sn-glycero-3-phosphoethanolamine + H2O
-
 Homo sapiens 1-acyl-sn-glycero-3-phosphoethanolamine + arachidonic acid
-
 ?
3.1.1.4 1-acyl-2-linoleoyl-3-phosphoethanolamine + H2O
-
 Homo sapiens 1-acyl-3-phosphoethanolamine + linolic acid
-
 ?
3.1.1.4 1-acyl-2-linoleoyl-glycerophosphocholine + H2O
-
 Homo sapiens 1-acyl-glycerophosphocholine + linolic acid
-
 ?
3.1.1.4 phospholipids + H2O release of arachidonic acid: biosynthesis of leucotrienes, thromboxans and prostaglandins Homo sapiens ?
-
 ?

Subunits

EC Number Subunits Comment Organism
3.1.1.4 monomer
-
 Homo sapiens

pH Stability

EC Number pH Stability pH Stability Maximum Comment Organism
3.1.1.4 2
-
 exposure to acidic conditions, i.e. pH 2 for 60 min at 4°C, causes irreversible loss of activity, stable in basic medium Homo sapiens