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Literature summary extracted from

  • Tomita, T.; Sawamura, F.; Uetsuka, R.; Chiba, T.; Miura, S.; Ikeda, M.; Tomita, I.
    Inhibition of cholesterylester accumulation by 17beta-estradiol in macrophages through activation of neutral cholesterol esterase (1996), Biochim. Biophys. Acta, 1300, 210-218.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.1.1.13 17beta-estradiol enhanced hydrolysis of cholesteryl oleate in time- and dose-dependent manner Mus musculus
3.1.1.13 cAMP-dependent protein kinase type II increasing activity on cholesteryl oleate hydrolysis, increasing protein kinase synthesis due to addition of 17beta-estradiol Mus musculus

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.1.13 progesterone 38% inhibition at 0.06 mM Mus musculus
3.1.1.13 testosterone 19% inhibition at 0.035 mM Mus musculus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.1.1.13 0.005
-
cholesteryl oleate in presence of cofactors Mus musculus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.1.1.13 Mg2+ activation in a reaction mixture containing cAMP, protein kinase A and ATP Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.1.13 cholesteryl esters + H2O Mus musculus involvement in arteriosclerosis cholesterol + fatty acid
-
r

Organism

EC Number Organism UniProt Comment Textmining
3.1.1.13 Mus musculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.1.13 macrophage J774 A.1 cells Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.1.13 cholesteryl esters + H2O involvement in arteriosclerosis Mus musculus cholesterol + fatty acid
-
r
3.1.1.13 cholesteryl oleate + H2O
-
Mus musculus cholesterol + oleic acid
-
r

Synonyms

EC Number Synonyms Comment Organism
3.1.1.13 N-CEase
-
Mus musculus
3.1.1.13 neutral cholesterol esterase
-
Mus musculus

Cofactor

EC Number Cofactor Comment Organism Structure
3.1.1.13 cAMP as cofactor for cAMP-dependent protein kinase Mus musculus
3.1.1.13 MgATP2-
-
Mus musculus