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Literature summary extracted from

  • Tanaka, H.; Mierau, I.; Ito, F.
    Purification and characterization of bovine pancreatic bile salt-activated lipase (1999), J. Biochem., 125, 883-890.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.1.1.13 sodium taurocholic acid strongly activated lipase Bos taurus
3.1.1.13 sodium taurocholic acid activation on esterase Homo sapiens
3.1.1.13 sodium taurocholic acid activation on esterase Bos taurus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.1.1.13 extracellular
-
 Homo sapiens
-
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.1.1.13 65000
-
 SDS-PAGE Bos taurus
3.1.1.13 105000
-
 SDS-PAGE Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.1.13 cholesteryl esters + H2O Bos taurus
-
 cholesterol + fatty acid
-
 ?
3.1.1.13 cholesteryl esters + H2O Homo sapiens important role in fat digestion in infants cholesterol + fatty acid
-
 r
3.1.1.13 fat-soluble vitamin esters + H2O Homo sapiens
-
 vitamin + ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.1.13 Bos taurus
-
-
-
3.1.1.13 Homo sapiens
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
3.1.1.13 side-chain modification glycoprotein, contains fucose, galactose and sialic acid Homo sapiens
3.1.1.13 side-chain modification glycoprotein, contains only fucose residues Bos taurus

Purification (Commentary)

EC Number Purification (Comment) Organism
3.1.1.13 2-step chromatography techniques to homogeneity Homo sapiens
3.1.1.13 4-step chromatography techniques to homogeneity Bos taurus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.1.13 milk
-
 Homo sapiens
-
3.1.1.13 pancreas
-
 Bos taurus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
3.1.1.13 1.23
-
 lipase activity in absence of sodium taurocholic acid Bos taurus
3.1.1.13 15.7
-
 esterase activity in absence of sodium taurocholic acid Bos taurus
3.1.1.13 47.7
-
 esterase activity in absence of sodium taurocholic acid Homo sapiens
3.1.1.13 51.6
-
 lipase activity in presence of 10 mM sodium taurocolic acid Bos taurus
3.1.1.13 51.6
-
 esterase activity in presence of 10 mM sodium taurocholic acid Bos taurus
3.1.1.13 98.1
-
 esterase activity in presence of 10 mM sodium taurocholic acid Homo sapiens
3.1.1.13 234.6
-
 lipase activity in presence of 10 mM sodium taurocholic acid Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.1.13 cholesteryl esters + H2O
-
 Bos taurus cholesterol + fatty acid
-
 ?
3.1.1.13 cholesteryl esters + H2O important role in fat digestion in infants Homo sapiens cholesterol + fatty acid
-
 r
3.1.1.13 fat-soluble vitamin esters + H2O
-
 Homo sapiens vitamin + ?
-
 ?
3.1.1.13 p-nitrophenyl acetate + H2O
-
 Homo sapiens p-nitrophenol + acetic acid
-
 r
3.1.1.13 p-nitrophenyl acetate + H2O
-
 Bos taurus p-nitrophenol + acetic acid
-
 r
3.1.1.13 triolein + H2O
-
 Homo sapiens dioleoylglycerol + oleic acid
-
 r
3.1.1.13 triolein + H2O
-
 Bos taurus dioleoylglycerol + oleic acid
-
 r

Subunits

EC Number Subunits Comment Organism
3.1.1.13 monomer 1 * 65000, SDS-PAGE Bos taurus
3.1.1.13 monomer 1 * 105000, SDS-PAGE Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
3.1.1.13 bile salt-activated lipase
-
 Homo sapiens
3.1.1.13 bile salt-activated lipase
-
 Bos taurus