Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Izumi, Y.; Tani, Y.; Ogata, K.
    Microbiological biosynthesis of biotin (1979), Methods Enzymol., 62, 326-338.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.6.1.62 As5+
-
Corynebacterium glutamicum
2.6.1.62 Co2+
-
Corynebacterium glutamicum
2.6.1.62 HgCl2
-
Corynebacterium glutamicum
2.6.1.62 hydroxylamine
-
Corynebacterium glutamicum
2.6.1.62 iodoacetate
-
Corynebacterium glutamicum
2.6.1.62 isoniazid
-
Corynebacterium glutamicum
2.6.1.62 p-chloromercuribenzoate
-
Corynebacterium glutamicum
2.6.1.62 phenylhydrazine
-
Corynebacterium glutamicum
2.6.1.62 Semicarbazide
-
Corynebacterium glutamicum
6.3.3.3 1,10-phenanthroline
-
Pseudomonas graveolens
6.3.3.3 2,2'-dipyridyl
-
Pseudomonas graveolens
6.3.3.3 7,8-diaminononanoate competitive to diaminobiotin Pseudomonas graveolens
6.3.3.3 ADP competitive to ATP Pseudomonas graveolens
6.3.3.3 Diaminobiotin competitive to 7,8-diaminononanoate Pseudomonas graveolens
6.3.3.3 EDTA
-
Pseudomonas graveolens

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
6.3.3.3 Fe2+ 71-91% of the activity relative to Mg2+ Pseudomonas graveolens
6.3.3.3 Mg2+ required Pseudomonas graveolens
6.3.3.3 Mn2+ 95-136% of the activity relative to Mg2+ Pseudomonas graveolens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.6.1.62 S-adenosyl-L-methionine + 8-amino-7-oxononanoate Salmonella enterica subsp. enterica serovar Typhimurium biotin synthesis S-adenosyl-4-methylthio-2-oxobutanoate + 7,8-diaminononanoate
-
?
2.6.1.62 S-adenosyl-L-methionine + 8-amino-7-oxononanoate Kocuria rosea biotin synthesis S-adenosyl-4-methylthio-2-oxobutanoate + 7,8-diaminononanoate
-
?
2.6.1.62 S-adenosyl-L-methionine + 8-amino-7-oxononanoate Bacillus roseus biotin synthesis S-adenosyl-4-methylthio-2-oxobutanoate + 7,8-diaminononanoate
-
?
2.6.1.62 S-adenosyl-L-methionine + 8-amino-7-oxononanoate Corynebacterium glutamicum biotin synthesis S-adenosyl-4-methylthio-2-oxobutanoate + 7,8-diaminononanoate
-
?
2.6.1.62 S-adenosyl-L-methionine + 8-amino-7-oxononanoate Bacillus roseus IAM 1257 biotin synthesis S-adenosyl-4-methylthio-2-oxobutanoate + 7,8-diaminononanoate
-
?

Organism

EC Number Organism UniProt Comment Textmining
2.6.1.62 Bacillus roseus
-
IAM 1257
-
2.6.1.62 Bacillus roseus IAM 1257
-
IAM 1257
-
2.6.1.62 Corynebacterium glutamicum
-
-
-
2.6.1.62 Kocuria rosea
-
IFO 3764
-
2.6.1.62 Salmonella enterica subsp. enterica serovar Typhimurium
-
AJ 2635, AJ 2636
-
6.3.3.3 Pseudomonas graveolens
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.6.1.62 homogeneity Corynebacterium glutamicum
6.3.3.3
-
Pseudomonas graveolens

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.6.1.62 19.9
-
-
Corynebacterium glutamicum

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.6.1.62 S-adenosyl-L-methionine + 7-amino-8-oxononanoate 1% of the activity of 8-amino-7-oxononanoate Corynebacterium glutamicum S-adenosyl-4-methylthio-2-oxobutanoate + 7,8-diaminononanoate
-
?
2.6.1.62 S-adenosyl-L-methionine + 8-amino-7-oxononanoate synonym: 7-keto-8-aminopelargonic acid, KAPA Salmonella enterica subsp. enterica serovar Typhimurium S-adenosyl-4-methylthio-2-oxobutanoate + 7,8-diaminononanoate
-
?
2.6.1.62 S-adenosyl-L-methionine + 8-amino-7-oxononanoate synonym: 7-keto-8-aminopelargonic acid, KAPA Kocuria rosea S-adenosyl-4-methylthio-2-oxobutanoate + 7,8-diaminononanoate
-
?
2.6.1.62 S-adenosyl-L-methionine + 8-amino-7-oxononanoate synonym: 7-keto-8-aminopelargonic acid, KAPA Bacillus roseus S-adenosyl-4-methylthio-2-oxobutanoate + 7,8-diaminononanoate
-
?
2.6.1.62 S-adenosyl-L-methionine + 8-amino-7-oxononanoate synonym: 7-keto-8-aminopelargonic acid, KAPA Corynebacterium glutamicum S-adenosyl-4-methylthio-2-oxobutanoate + 7,8-diaminononanoate
-
?
2.6.1.62 S-adenosyl-L-methionine + 8-amino-7-oxononanoate biotin synthesis Salmonella enterica subsp. enterica serovar Typhimurium S-adenosyl-4-methylthio-2-oxobutanoate + 7,8-diaminononanoate
-
?
2.6.1.62 S-adenosyl-L-methionine + 8-amino-7-oxononanoate biotin synthesis Kocuria rosea S-adenosyl-4-methylthio-2-oxobutanoate + 7,8-diaminononanoate
-
?
2.6.1.62 S-adenosyl-L-methionine + 8-amino-7-oxononanoate biotin synthesis Bacillus roseus S-adenosyl-4-methylthio-2-oxobutanoate + 7,8-diaminononanoate
-
?
2.6.1.62 S-adenosyl-L-methionine + 8-amino-7-oxononanoate biotin synthesis Corynebacterium glutamicum S-adenosyl-4-methylthio-2-oxobutanoate + 7,8-diaminononanoate
-
?
2.6.1.62 S-adenosyl-L-methionine + 8-amino-7-oxononanoate synonym: 7-keto-8-aminopelargonic acid, KAPA Bacillus roseus IAM 1257 S-adenosyl-4-methylthio-2-oxobutanoate + 7,8-diaminononanoate
-
?
2.6.1.62 S-adenosyl-L-methionine + 8-amino-7-oxononanoate biotin synthesis Bacillus roseus IAM 1257 S-adenosyl-4-methylthio-2-oxobutanoate + 7,8-diaminononanoate
-
?
6.3.3.3 ATP + 7,8-diaminononanoate + CO2
-
Pseudomonas graveolens ADP + phosphate + dethiobiotin
-
?
6.3.3.3 ATP + diaminobiotin + CO2
-
Pseudomonas graveolens ADP + phosphate + biotin
-
?
6.3.3.3 CTP + 7,8-diaminononanoate + CO2
-
Pseudomonas graveolens CDP + phosphate + dethiobiotin
-
?
6.3.3.3 GTP + 7,8-diaminononanoate + CO2
-
Pseudomonas graveolens GDP + phosphate + dethiobiotin
-
?
6.3.3.3 ITP + 7,8-diaminononanoate + CO2
-
Pseudomonas graveolens IDP + phosphate + dethiobiotin
-
?
6.3.3.3 UTP + 7,8-diaminononanoate + CO2
-
Pseudomonas graveolens UDP + phosphate + dethiobiotin
-
?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.6.1.62 37
-
-
Corynebacterium glutamicum
6.3.3.3 50 55
-
Pseudomonas graveolens

Temperature Stability [°C]

EC Number Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
2.6.1.62 7 60 10 min, stable Corynebacterium glutamicum

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.6.1.62 8.5
-
-
Corynebacterium glutamicum
6.3.3.3 7 8
-
Pseudomonas graveolens

pH Stability

EC Number pH Stability pH Stability Maximum Comment Organism
2.6.1.62 7 11 30 min, stable Corynebacterium glutamicum

Cofactor

EC Number Cofactor Comment Organism Structure
2.6.1.62 pyridoxal 5'-phosphate cofactor Salmonella enterica subsp. enterica serovar Typhimurium
2.6.1.62 pyridoxal 5'-phosphate cofactor Kocuria rosea
2.6.1.62 pyridoxal 5'-phosphate cofactor Bacillus roseus
2.6.1.62 pyridoxal 5'-phosphate cofactor Corynebacterium glutamicum
2.6.1.62 pyridoxamine 5'-phosphate active as cofactor Salmonella enterica subsp. enterica serovar Typhimurium
2.6.1.62 pyridoxamine 5'-phosphate active as cofactor Kocuria rosea
2.6.1.62 pyridoxamine 5'-phosphate active as cofactor Bacillus roseus
2.6.1.62 pyridoxamine 5'-phosphate active as cofactor Corynebacterium glutamicum