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Literature summary extracted from

  • Storey, K.B.; Storey, J.M.
    Kinetic characterization of tissue-specific isozymes of octopine dehydrogenase from mantle muscle and brain of Sepia officinalis (1979), Eur. J. Biochem., 93, 545-552.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.5.1.11 L-Arg
-
 Sepia officinalis
1.5.1.11 NAD+
-
 Sepia officinalis
1.5.1.11 octopine substrate inhibition and product inhibition Sepia officinalis
1.5.1.11 pyruvate brain enzyme shows strong substrate inhibition, mantle muscle enzyme only slight inhibition Sepia officinalis

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.5.1.11 0.02
-
 NADH brain enzyme Sepia officinalis
1.5.1.11 0.03
-
 NADH mantle muscle enzyme Sepia officinalis
1.5.1.11 0.09
-
 octopine brain enzyme Sepia officinalis
1.5.1.11 0.11
-
 NAD+ brain enzyme Sepia officinalis
1.5.1.11 0.25
-
 pyruvate brain enzyme Sepia officinalis
1.5.1.11 0.25
-
 pyruvate NAD+, mantle muscle enzyme Sepia officinalis
1.5.1.11 0.3
-
 Arg pyruvate, mantle muscle enzyme Sepia officinalis
1.5.1.11 0.4
-
 pyruvate Arg, brain enzyme Sepia officinalis
1.5.1.11 0.85
-
 octopine octopine, mantle muscle enzyme Sepia officinalis
1.5.1.11 3.2
-
 D-lysopine L-Arg, mantle muscle enzyme Sepia officinalis

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.5.1.11 additional information Sepia officinalis the major role of the brain enzyme may be the oxidation of octopine ?
-
 ?
1.5.1.11 additional information Sepia officinalis mantle muscle enzyme appears geared for the rapid synthesis of octopine under conditions of muscular work ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.5.1.11 Sepia officinalis
-
 kinetically distinct tissue-specific isoenzymes
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.5.1.11 brain
-
 Sepia officinalis
-
1.5.1.11 mantle muscle
-
 Sepia officinalis
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.5.1.11 L-Arg + pyruvate + NADH
-
 Sepia officinalis N2-(D-1-carboxyethyl)-L-Arg + NAD+ + H2O
-
 ?
1.5.1.11 L-Lys + pyruvate + NADH
-
 Sepia officinalis Lysopine + NAD+ + H2O
-
 ?
1.5.1.11 additional information the major role of the brain enzyme may be the oxidation of octopine Sepia officinalis ?
-
 ?
1.5.1.11 additional information mantle muscle enzyme appears geared for the rapid synthesis of octopine under conditions of muscular work Sepia officinalis ?
-
 ?

Cofactor

EC Number Cofactor Comment Organism Structure
1.5.1.11 NADH
-
 Sepia officinalis