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Literature summary extracted from

  • Bertrand, R.; Beauchemin, M.; Dayan, A.; Ouimet, M.; Jolivet, J.
    Identification and characterization of human mitochondrial methenyltetrahydrofolate synthetase activity (1995), Biochim. Biophys. Acta, 1266, 245-2549.
    View publication on PubMed

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
6.3.3.2 0.0008
-
 (6S)-5-formyltetrahydropteroyl pentaglutamate mitochondrial enzyme Homo sapiens
6.3.3.2 0.0047
-
 (6R,S)-5-formyltetrahydropteroyl-Glu
-
 Homo sapiens
6.3.3.2 0.022
-
 ATP
-
 Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
6.3.3.2 cytosol 85% of the total MTHFS activity is in the cytoplasm Homo sapiens 5829
-
6.3.3.2 mitochondrion matrix Homo sapiens 5739
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
6.3.3.2 25000
-
 gel filtration, mitochondrial enzyme Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
6.3.3.2 Homo sapiens
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
6.3.3.2
-
 Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
6.3.3.2 CA-46 cell
-
 Homo sapiens
-
6.3.3.2 liver
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.3.3.2 ATP + (6R,S)-5-formyltetrahydropteroyl-Glu
-
 Homo sapiens ?
-
 ?
6.3.3.2 ATP + (6S)-5-formyltetrahydropteroyl-pentaglutamate
-
 Homo sapiens ?
-
 ?
6.3.3.2 ATP + 5-formyltetrahydrofolate
-
 Homo sapiens ADP + phosphate + 5,10-methylenetetrahydrofolate
-
 ?