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Literature summary extracted from

  • Li, M.; Collier, C.; Gritsman, H.; Bertino, J.R.
    Activity of 5,10-methenyltetrahydrofolate synthetase in rat tissues and in tumor cell lines (1990), Pteridines, 2, 75-79.
No PubMed abstract available

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
6.3.3.2 0.0051
-
 5-formyltetrahydrofolate
-
 Rattus norvegicus
6.3.3.2 0.05
-
 ATP
-
 Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
6.3.3.2 ATP + 5-formyltetrahydrofolate Homo sapiens
-
 ?
-
 ?
6.3.3.2 ATP + 5-formyltetrahydrofolate Rattus norvegicus key enzymatic reaction in the pathway by which 5-formyltetrahydrofolate enters the folate coenzyme pool ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
6.3.3.2 Cricetulus griseus
-
-
-
6.3.3.2 Homo sapiens
-
-
-
6.3.3.2 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
6.3.3.2 bone marrow
-
 Rattus norvegicus
-
6.3.3.2 brain low activity Rattus norvegicus
-
6.3.3.2 CEM cell T-lymphoblast cell line CEM and its methotrexate resistant subline, colon tumor cell line Homo sapiens
-
6.3.3.2 CHO cell CHO, ovary cell line and its methotrexate resistant subline Cricetulus griseus
-
6.3.3.2 colon
-
 Rattus norvegicus
-
6.3.3.2 colonic cancer cell line
-
 Cricetulus griseus
-
6.3.3.2 colonic cancer cell line T-lymphoblast cell line CEM and its methotrexate resistant subline, colon tumor cell line Homo sapiens
-
6.3.3.2 intestine
-
 Rattus norvegicus
-
6.3.3.2 kidney
-
 Rattus norvegicus
-
6.3.3.2 liver
-
 Homo sapiens
-
6.3.3.2 liver highest activity compared to other tissues Rattus norvegicus
-
6.3.3.2 lung low activity Rattus norvegicus
-
6.3.3.2 muscle low activity Rattus norvegicus
-
6.3.3.2 spleen
-
 Rattus norvegicus
-
6.3.3.2 testis
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.3.3.2 ATP + 5-formyltetrahydrofolate
-
 Cricetulus griseus ADP + phosphate + 5,10-methylenetetrahydrofolate
-
 ?
6.3.3.2 ATP + 5-formyltetrahydrofolate
-
 Homo sapiens ADP + phosphate + 5,10-methylenetetrahydrofolate
-
 ?
6.3.3.2 ATP + 5-formyltetrahydrofolate
-
 Rattus norvegicus ADP + phosphate + 5,10-methylenetetrahydrofolate
-
 ?
6.3.3.2 ATP + 5-formyltetrahydrofolate
-
 Homo sapiens ?
-
 ?
6.3.3.2 ATP + 5-formyltetrahydrofolate key enzymatic reaction in the pathway by which 5-formyltetrahydrofolate enters the folate coenzyme pool Rattus norvegicus ?
-
 ?