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Literature summary extracted from

  • Emanuele, J.J.; Jin, H.; Jacobson, B.L.; Chang, C.Y.; Einspahr, H.M.; Villafranca, J.J.
    Kinetic and crystallographic studies of Escherichia coli UDP-N-acetylmuramate:L-alanine ligase (1996), Protein Sci., 5, 2566-2574.
    View publication on PubMedView publication on EuropePMC

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
6.3.2.8
-
Escherichia coli

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
6.3.2.8 0.044
-
UDP-N-acetylmuramate
-
Escherichia coli
6.3.2.8 0.046
-
beta-Ala
-
Escherichia coli
6.3.2.8 0.048
-
L-Ala
-
Escherichia coli
6.3.2.8 0.13
-
ATP
-
Escherichia coli
6.3.2.8 0.14
-
ATP beta-chloro-L-Ala Escherichia coli
6.3.2.8 0.19
-
beta-cyano-L-Ala
-
Escherichia coli
6.3.2.8 0.2
-
L-Ala 2-amino-tert-butylpropionate Escherichia coli
6.3.2.8 0.22
-
UDP-N-acetyl-alpha-D-muramate
-
Escherichia coli
6.3.2.8 0.36
-
benzyl L-alaninate
-
Escherichia coli
6.3.2.8 0.44
-
L-Vinylglycine
-
Escherichia coli
6.3.2.8 0.5
-
methyl L-alaninate
-
Escherichia coli
6.3.2.8 0.59
-
ethyl L-alaninate
-
Escherichia coli
6.3.2.8 1.1
-
DL-propargylglycine
-
Escherichia coli
6.3.2.8 1.2
-
L-Ser
-
Escherichia coli
6.3.2.8 3.8
-
L-Cys
-
Escherichia coli
6.3.2.8 4.3
-
2-amino-n-butyric acid
-
Escherichia coli
6.3.2.8 7.9
-
2-aminopropionamide
-
Escherichia coli
6.3.2.8 10
-
Gly
-
Escherichia coli
6.3.2.8 16
-
2-amino-N-hydroxymethyl propionamide
-
Escherichia coli
6.3.2.8 25
-
L-Thr
-
Escherichia coli
6.3.2.8 40
-
L-Ile
-
Escherichia coli
6.3.2.8 62
-
N-(2-aminopropionyl)piperidine
-
Escherichia coli
6.3.2.8 70
-
L-Val
-
Escherichia coli

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
6.3.2.8 Co2+ support activity Escherichia coli
6.3.2.8 Mg2+ support activity Escherichia coli
6.3.2.8 Mn2+ supports activity Escherichia coli

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
6.3.2.8 ATP + UDP-N-acetylmuramate + L-Ala Escherichia coli adds the first amino acid to the sugar moiety of the peptidoglycan precursor, catalyzing one essential step in cell wall biosynthesis ?
-
?

Organism

EC Number Organism UniProt Comment Textmining
6.3.2.8 Escherichia coli
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.3.2.8 ATP + UDP-N-acetyl-alpha-D-muramate + L-alanine
-
Escherichia coli ADP + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanine
-
?
6.3.2.8 ATP + UDP-N-acetylmuramate + 2-amino-benzylpropionate
-
Escherichia coli ADP + phosphate + UDP-N-acetylmuramoyl-2-amino-benzylpropionate
-
?
6.3.2.8 ATP + UDP-N-acetylmuramate + 2-amino-ethylpropionate
-
Escherichia coli ADP + phosphate + UDP-N-acetylmuramoyl-2-amino-ethylpropionate
-
?
6.3.2.8 ATP + UDP-N-acetylmuramate + 2-amino-methylpropionate
-
Escherichia coli ADP + phosphate + UDP-N-acetylmuramoyl-2-amino-methylpropionate
-
?
6.3.2.8 ATP + UDP-N-acetylmuramate + 2-amino-N-butyric acid
-
Escherichia coli ADP + phosphate + UDP-N-acetylmuramoyl-2-amino-N-butyric acid
-
?
6.3.2.8 ATP + UDP-N-acetylmuramate + 2-amino-N-hydroxymethyl propionamide
-
Escherichia coli ADP + phosphate + UDP-N-acetylmuramoyl-2-amino-N-hydroxymethylpropionamide
-
?
6.3.2.8 ATP + UDP-N-acetylmuramate + 2-amino-propionamide
-
Escherichia coli ADP + phosphate + UDP-N-acetylmuramoyl-2-aminopropionamide
-
?
6.3.2.8 ATP + UDP-N-acetylmuramate + 2-amino-tert-butylpropionate
-
Escherichia coli ADP + phosphate + UDP-N-acetylmuramoyl-2-amino-tert-butylpropionate
-
?
6.3.2.8 ATP + UDP-N-acetylmuramate + benzyl L-alaninate
-
Escherichia coli ADP + phosphate + benzyl UDP-N-acetylmuramoyl-L-alanine
-
?
6.3.2.8 ATP + UDP-N-acetylmuramate + beta-Ala
-
Escherichia coli ADP + phosphate + UDP-N-acetylmuramoyl-beta-Ala
-
?
6.3.2.8 ATP + UDP-N-acetylmuramate + beta-chloro-L-Ala
-
Escherichia coli ADP + phosphate + UDP-N-acetylmuramoyl-beta-chloro-L-Ala
-
?
6.3.2.8 ATP + UDP-N-acetylmuramate + beta-cyano-L-Ala
-
Escherichia coli ADP + phosphate + UDP-N-acetylmuramoyl-beta-cyano-L-Ala
-
?
6.3.2.8 ATP + UDP-N-acetylmuramate + DL-propargylglycine
-
Escherichia coli ADP + phosphate + UDP-N-acetylmuramoyl-DL-propargylglycine
-
?
6.3.2.8 ATP + UDP-N-acetylmuramate + DL-Ser
-
Escherichia coli ADP + phosphate + UDP-N-acetylmuramoyl-DL-Ser
-
?
6.3.2.8 ATP + UDP-N-acetylmuramate + ethyl L-alaninate
-
Escherichia coli ADP + phosphate + ethyl UDP-N-acetylmuramoyl-L-alaninate
-
?
6.3.2.8 ATP + UDP-N-acetylmuramate + Gly
-
Escherichia coli ADP + phosphate + UDP-N-acetylmuramoyl-Gly
-
?
6.3.2.8 ATP + UDP-N-acetylmuramate + L-Ala
-
Escherichia coli ADP + phosphate + UDP-N-acetylmuramoyl-L-Ala
-
?
6.3.2.8 ATP + UDP-N-acetylmuramate + L-Ala adds the first amino acid to the sugar moiety of the peptidoglycan precursor, catalyzing one essential step in cell wall biosynthesis Escherichia coli ?
-
?
6.3.2.8 ATP + UDP-N-acetylmuramate + L-Cys
-
Escherichia coli ADP + phosphate + UDP-N-acetylmuramoyl-L-Cys
-
?
6.3.2.8 ATP + UDP-N-acetylmuramate + L-Ile
-
Escherichia coli ADP + phosphate + UDP-N-acetylmuramoyl-L-Ile
-
?
6.3.2.8 ATP + UDP-N-acetylmuramate + L-serine
-
Escherichia coli ADP + phosphate + UDP-N-acetylmuramoyl-L-serine
-
?
6.3.2.8 ATP + UDP-N-acetylmuramate + L-Thr
-
Escherichia coli ADP + phosphate + UDP-N-acetylmuramoyl-L-Thr
-
?
6.3.2.8 ATP + UDP-N-acetylmuramate + L-Val
-
Escherichia coli ADP + phosphate + UDP-N-acetylmuramoyl-L-Val
-
?
6.3.2.8 ATP + UDP-N-acetylmuramate + L-vinylglycine
-
Escherichia coli ADP + phosphate + UDP-N-acetylmuramoyl-L-vinylglycine
-
?
6.3.2.8 ATP + UDP-N-acetylmuramate + methyl L-alaninate
-
Escherichia coli ADP + phosphate + methyl UDP-N-acetylmuramoyl-L-alaninate
-
?
6.3.2.8 ATP + UDP-N-acetylmuramate + N-(2-aminopropionyl)piperidine
-
Escherichia coli ADP + phosphate + UDP-N-acetylmuramoyl-N-(2-aminopropionyl)piperidine
-
?
6.3.2.8 additional information the enzyme hydrolyzes ATP in absence of L-Ala. This L-Ala independent activity is dependent upon the concentration of both ATP and UDP-N-acetylmuramate Escherichia coli ?
-
?

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
6.3.2.8 additional information
-
additional information
-
Escherichia coli
6.3.2.8 2.5
-
beta-Alanine
-
Escherichia coli
6.3.2.8 5.17
-
L-Ile
-
Escherichia coli
6.3.2.8 6.17
-
N-(2-aminopropionyl)piperidine
-
Escherichia coli
6.3.2.8 11.7
-
2-amino-N-hydroxymethylpropionamide
-
Escherichia coli
6.3.2.8 13.5
-
2-amino-benzylpropionate
-
Escherichia coli
6.3.2.8 15.2
-
2-amino-ethylpropionate
-
Escherichia coli
6.3.2.8 15.3
-
L-Vinylglycine
-
Escherichia coli
6.3.2.8 16.3
-
L-Ala
-
Escherichia coli
6.3.2.8 18.3
-
2-amino-propionamide
-
Escherichia coli
6.3.2.8 20
-
L-Cys
-
Escherichia coli
6.3.2.8 20
-
DL-propargylglycine
-
Escherichia coli
6.3.2.8 20
-
beta-chloro-Ala
-
Escherichia coli
6.3.2.8 21.7
-
Gly
-
Escherichia coli
6.3.2.8 21.7
-
L-Val
-
Escherichia coli
6.3.2.8 21.7
-
2-amino-tert-butylpropionate
-
Escherichia coli
6.3.2.8 23.3
-
L-Thr
-
Escherichia coli
6.3.2.8 25
-
L-Ser
-
Escherichia coli
6.3.2.8 25
-
2-amino-n-butyric acid
-
Escherichia coli
6.3.2.8 26.7
-
beta-cyano-L-Ala
-
Escherichia coli
6.3.2.8 28.3
-
2-amino-methylpropionate
-
Escherichia coli