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Literature summary extracted from

  • Meister, A.
    Glutathione synthetase from rat kidney (1985), Methods Enzymol., 113, 393-399.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
6.3.2.3 PCMB
-
 Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
6.3.2.3 0.033
-
 ATP
-
 Rattus norvegicus
6.3.2.3 0.76
-
 Gly
-
 Rattus norvegicus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
6.3.2.3 K+ strict requirement for monovalent cation, maximal activity with K+ Rattus norvegicus
6.3.2.3 Li+ can replace K+ Rattus norvegicus
6.3.2.3 NH4+ can replace K+ Rattus norvegicus
6.3.2.3 Rb+ can replace K+ Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
6.3.2.3 Rattus norvegicus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
6.3.2.3
-
 Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
6.3.2.3 kidney
-
 Rattus norvegicus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
6.3.2.3 13.75
-
-
 Rattus norvegicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.3.2.3 ATP + beta-aminoglutaryl-L-2-aminobutyrate + Gly
-
 Rattus norvegicus ADP + phosphate + beta-aminoglutaryl-L-2-aminobutyryl-Gly
-
 ?
6.3.2.3 ATP + gamma-Glu-aminobutyrate + Gly D-gamma-Glu-L-2-aminobutyrate Rattus norvegicus ADP + phosphate + ophthalmic acid
-
 ?
6.3.2.3 ATP + gamma-Glu-L-Cys + Ala
-
 Rattus norvegicus ADP + phosphate + gamma-Glu-Cys-Ala
-
 ?
6.3.2.3 ATP + gamma-Glu-L-Cys + Gly
-
 Rattus norvegicus ADP + phosphate + glutathione
-
 ?
6.3.2.3 ATP + gamma-Glu-L-Cys + Ser
-
 Rattus norvegicus ADP + phosphate + gamma-Glu-Cys-Ser
-
 ?
6.3.2.3 dATP + gamma-Glu-L-Cys + Gly
-
 Rattus norvegicus dADP + phosphate + glutathione
-
 ?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
6.3.2.3 8 8.5
-
 Rattus norvegicus