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Literature summary extracted from

  • Moran, R.G.; Colman, P.D.
    Mammalian folyl polyglutamate synthetase: Partial purification and properties of the mouse liver enzyme (1984), Biochemistry, 23, 4580-4589.
    View publication on PubMed

General Stability

EC Number General Stability Organism
6.3.2.17 stabilized by glycerol or by ATP Mus musculus

Inhibitors

EC Number Inhibitors Comment Organism Structure
6.3.2.17 (NH4)2SO4
-
 Mus musculus
6.3.2.17 ADP
-
 Mus musculus
6.3.2.17 AMP
-
 Mus musculus
6.3.2.17 diphosphate
-
 Mus musculus
6.3.2.17 phosphate
-
 Mus musculus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
6.3.2.17 0.0039
-
 10-formyl-5,6,7,8-tetrahydropteroyl-Glu
-
 Mus musculus
6.3.2.17 0.0048
-
 5,10-methylene-5,6,7,8-tetrahydropteroyl-Glu
-
 Mus musculus
6.3.2.17 0.007
-
 5,6,7,8-tetrahydropteroyl-Glu
-
 Mus musculus
6.3.2.17 0.0081
-
 5-formyl-5,6,7,8-tetrahydropteroyl-Glu
-
 Mus musculus
6.3.2.17 0.0086
-
 7,8-dihydropteroyl-Glu
-
 Mus musculus
6.3.2.17 0.137
-
 pteroyl-Glu
-
 Mus musculus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
6.3.2.17 Mg2+
-
 Mus musculus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
6.3.2.17 65000
-
 gel filtration Mus musculus

Organism

EC Number Organism UniProt Comment Textmining
6.3.2.17 Mus musculus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
6.3.2.17 liver, partial Mus musculus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
6.3.2.17 liver
-
 Mus musculus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
6.3.2.17 additional information
-
-
 Mus musculus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.3.2.17 ADP + phosphate + 7,8-dihydropteroyl-Glu
-
 Mus musculus ATP + 7,8-dihydropteroate + L-glutamate
-
 ?
6.3.2.17 ATP + (6S)-5,6,7,8-tetrahydropteroylglutamate + L-glutamate
-
 Mus musculus ADP + phosphate + (6S)-5,6,7,8-tetrahydropteroyl-Glu2
-
 ?
6.3.2.17 ATP + 10-formyl-5,6,7,8-tetrahydropteroyl-Glu + Glu
-
 Mus musculus ADP + phosphate + 10-formyl-5,6,7,8-tetrahydropteroyl-Glu2
-
 ?
6.3.2.17 ATP + 5,10-methylene-5,6,7,8-tetrahydropteroyl-gamma-Glun + Glu n:1 Mus musculus ADP + phosphate + 5,10-methylene-5,6,7,8-tetrahydropteroyl-gamma-Glun+1
-
 ?
6.3.2.17 ATP + 5,10-methylene-5,6,7,8-tetrahydropteroyl-Glu + L-glutamate
-
 Mus musculus ADP + phosphate + 5,10-methylene-5,6,7,8-tetrahydropteroyl-gamma-Glu2
-
 ?
6.3.2.17 ATP + 5,6,7,8-tetrahydropteroyl-Glun + Glu n: 1 Mus musculus ADP + phosphate + 5,6,7,8-tetrahydropteroyl-gamma-Glun+1
-
 ?
6.3.2.17 ATP + 5-formyl-5,6,7,8-tetrahydropteroyl-gamma-Glun + Glu
-
 Mus musculus ADP + phosphate + 5-formyl-5,6,7,8-tetrahydropteroyl-gamma-Glu2
-
 ?
6.3.2.17 ATP + 7,8-dihydropteroyl-Glun + Glu n: 1 Mus musculus ADP + phosphate + 7,8-dihydropteroyl-Glun+1
-
 ?
6.3.2.17 ATP + pteroyl-Glu + Glu
-
 Mus musculus ADP + phosphate + pteroylmonoglutamyl-Glu
-
 ?
6.3.2.17 additional information most effective substrates are: 7,8-dihydrofolate, 5,6,7,8-tetrahydrofolate, 5,10-methylenetetrahydrofolate, 10-formyltetrahydrofolate, 5-formyltetrahydrofolate Mus musculus ?
-
 ?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
6.3.2.17 8.2 9.5
-
 Mus musculus