Literature summary extracted from

Schoo, M.M.J.; Pristupa, Z.B.; Vickers, P.J.; Scrimgeour, K.G.
Folate analogues as substrates of mammalian folylpolyglutamate synthetase (1985), Cancer Res., 45, 3034-3041.

KM Value [mM]

EC Number	KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
6.3.2.17	0.025	-	aminopterin	-	Bos taurus
6.3.2.17	0.1	-	methotrexate	-	Bos taurus

Organism

EC Number	Organism	UniProt	Comment	Textmining
6.3.2.17	Bos taurus	-	-	-
6.3.2.17	Rattus norvegicus	-	-	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
6.3.2.17	liver	-	Rattus norvegicus	-
6.3.2.17	liver	-	Bos taurus	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
6.3.2.17	ATP + aminopterin + Glu	-	Rattus norvegicus	ADP + phosphate + aminopteryl-Glu	-	?
6.3.2.17	ATP + aminopterin + Glu	-	Bos taurus	ADP + phosphate + aminopteryl-Glu	-	?
6.3.2.17	ATP + methotrexate + Glu	-	Rattus norvegicus	ADP + phosphate + methotrexyl-Glu	-	?
6.3.2.17	ATP + methotrexate + Glu	-	Bos taurus	ADP + phosphate + methotrexyl-Glu	-	?

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Release 2023.1 (January 2023)