Literature summary extracted from

  • Cook, J.D.; Cichowicz, D.J.; George, S.; Lawler, A.; Shane, B.
    Mammalian folylpoly-gamma-glutamate synthetase. 4. In vitro and in vivo metabolism of folates and analogues and regulation of folate homeostasis (1987), Biochemistry, 26, 530-539.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
6.3.2.17 5,6,7,8-Tetrahydropteroyl-Orn inhibits reaction with 5,6,7,8-tetrahydropteroyl-Glu + ATP and pteroylmonoglutamate + ATP Sus scrofa
6.3.2.17 aminopterin inhibits reaction with pteroylmonoglutamate + ATP Sus scrofa

Organism

EC Number Organism UniProt Comment Textmining
6.3.2.17 Cricetulus griseus
-
-
-
6.3.2.17 Sus scrofa
-
hog
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
6.3.2.17 liver
-
Sus scrofa
-
6.3.2.17 ovary
-
Cricetulus griseus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.3.2.17 ATP + aminopterin + Glu
-
Sus scrofa ADP + phosphate + aminopteryl-Glu products with a glutamate chain length of 2-4 are formed ?
6.3.2.17 ATP + dihydroaminopterin + Glu
-
Sus scrofa ADP + phosphate + dihydroaminopteryl-Glu
-
?
6.3.2.17 ATP + methotrexate + Glu
-
Sus scrofa ADP + phosphate + methotrexyl-Glu
-
?
6.3.2.17 ATP + 5,6,7,8-tetrahydropteroyl-Glun + Glu n: 3 Sus scrofa ADP + phosphate + 5,6,7,8-tetrahydropteroyl-gamma-Glun+1
-
?
6.3.2.17 ATP + 5,6,7,8-tetrahydropteroyl-Glun + Glu n: 5 Sus scrofa ADP + phosphate + 5,6,7,8-tetrahydropteroyl-gamma-Glun+1
-
?
6.3.2.17 ATP + 5,6,7,8-tetrahydropteroyl-Glun + Glu n: 2 Sus scrofa ADP + phosphate + 5,6,7,8-tetrahydropteroyl-gamma-Glun+1
-
?
6.3.2.17 ATP + 5,6,7,8-tetrahydropteroyl-Glun + Glu n: 1 Sus scrofa ADP + phosphate + 5,6,7,8-tetrahydropteroyl-gamma-Glun+1
-
?
6.3.2.17 ATP + 5,6,7,8-tetrahydropteroyl-Glun + Glu n: 4 Sus scrofa ADP + phosphate + 5,6,7,8-tetrahydropteroyl-gamma-Glun+1
-
?
6.3.2.17 ATP + 5,6,7,8-tetrahydropteroyl-Glun + Glu n: 7 Sus scrofa ADP + phosphate + 5,6,7,8-tetrahydropteroyl-gamma-Glun+1
-
?
6.3.2.17 ATP + 5,6,7,8-tetrahydropteroyl-Glun + Glu n: 6 Sus scrofa ADP + phosphate + 5,6,7,8-tetrahydropteroyl-gamma-Glun+1
-
?
6.3.2.17 ATP + 5,10-methylene-5,6,7,8-tetrahydropteroyl-gamma-Glun + Glu n: 5 Sus scrofa ADP + phosphate + 5,10-methylene-5,6,7,8-tetrahydropteroyl-gamma-Glun+1
-
?
6.3.2.17 ATP + 5,10-methylene-5,6,7,8-tetrahydropteroyl-gamma-Glun + Glu n: 7 Sus scrofa ADP + phosphate + 5,10-methylene-5,6,7,8-tetrahydropteroyl-gamma-Glun+1
-
?
6.3.2.17 ATP + 5,10-methylene-5,6,7,8-tetrahydropteroyl-gamma-Glun + Glu n: 6 Sus scrofa ADP + phosphate + 5,10-methylene-5,6,7,8-tetrahydropteroyl-gamma-Glun+1
-
?
6.3.2.17 ATP + 5,10-methylene-5,6,7,8-tetrahydropteroyl-gamma-Glun + Glu n:1 Sus scrofa ADP + phosphate + 5,10-methylene-5,6,7,8-tetrahydropteroyl-gamma-Glun+1
-
?
6.3.2.17 ATP + 5-methyl-5,6,7,8-tetrahydropteroyl-gamma-Glun + Glu n: 2 Sus scrofa ADP + phosphate + 5-methyl-5,6,7,8-tetrahydropteroyl-gamma-Glun+1
-
?
6.3.2.17 ATP + 5-methyl-5,6,7,8-tetrahydropteroyl-gamma-Glun + Glu n: 1 Sus scrofa ADP + phosphate + 5-methyl-5,6,7,8-tetrahydropteroyl-gamma-Glun+1
-
?
6.3.2.17 ATP + 10-formyl-5,6,7,8-tetrahydropteroyl-Glu + Glu
-
Sus scrofa ADP + phosphate + 10-formyl-5,6,7,8-tetrahydropteroyl-Glu2
-
?
6.3.2.17 ATP + 5,6,7,8-tetrahydropteroyl-4-aminobutanoyl-Glu + Glu
-
Sus scrofa ADP + phosphate + 5,6,7,8-tetrahydropteroyl-4-aminobutanoyl-Glun n: 3-5 ?
6.3.2.17 ATP + 7,8-dihydropteroyl-Glun + Glu n: 5 Sus scrofa ADP + phosphate + 7,8-dihydropteroyl-Glun+1
-
?
6.3.2.17 ATP + 7,8-dihydropteroyl-Glun + Glu n: 2 Sus scrofa ADP + phosphate + 7,8-dihydropteroyl-Glun+1
-
?
6.3.2.17 ATP + 7,8-dihydropteroyl-Glun + Glu n: 1 Sus scrofa ADP + phosphate + 7,8-dihydropteroyl-Glun+1
-
?
6.3.2.17 ATP + 7,8-dihydropteroyl-4-aminobutanoyl-Glu + Glu
-
Sus scrofa ADP + phosphate + 7,8-dihydropteroyl-4-aminobutanoyl-Glun n: 3-5 ?
6.3.2.17 ATP + pteroyl-Glu + Glu n: 1, i.e. pteroylmonoglutamate, folic acid Sus scrofa ADP + phosphate + pteroylmonoglutamyl-Glu
-
?
6.3.2.17 ATP + homofolate + Glu
-
Sus scrofa ADP + phosphate + L-homocysteyl-Glu
-
?