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Literature summary extracted from

  • Ikeda, M.; Iwai, K.
    Some characteristics of the dihydrofolate synthetase from Serratia indica (1976), J. Nutr. Sci. Vitaminol., 22, 365-373.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
6.3.2.12 dihydrohomopteroic acid
-
 Serratia indica
6.3.2.12 Tetrahydrohomopteroate
-
 Serratia indica

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
6.3.2.12 0.00025
-
 7,8-dihydropteroate with addition of 100 mM K+ Serratia indica
6.3.2.12 0.0013
-
 7,8-dihydropteroate with addition of 7.5 mM K+ Serratia indica
6.3.2.12 0.22
-
 ATP with addition of 100 mM K+ Serratia indica
6.3.2.12 0.25
-
 L-Glu with addition of 100 mM K+ Serratia indica
6.3.2.12 0.29
-
 ATP with addition of 7.5 mM K+ Serratia indica
6.3.2.12 9.1
-
 L-Glu with addition of 7.5 mM K+ Serratia indica

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
6.3.2.12 Fe2+ divalent cation requirement is satisfied by Mg2+, Mn2+ or Fe2+ Serratia indica
6.3.2.12 K+ optimal concentration is 50 mM Serratia indica
6.3.2.12 K+ Km: 7 mM Serratia indica
6.3.2.12 K+ monovalent cation requirement is satisfied by K+, Rb+ or NH4+ Serratia indica
6.3.2.12 Mg2+ maximal activity at 5 mM, inhibition at higher concentration Serratia indica
6.3.2.12 Mg2+ divalent cation requirement is satisfied by Mg2+, Mn2+ or Fe2+ Serratia indica
6.3.2.12 Mn2+ divalent cation requirement is satisfied by Mg2+, Mn2+ or Fe2+ Serratia indica
6.3.2.12 NH4+ monovalent cation requirement is satisfied by K+, Rb+ or NH4+ Serratia indica
6.3.2.12 Rb+ monovalent cation requirement is satisfied by K+, Rb+ or NH4+ Serratia indica
6.3.2.12 Rb+ maximal activity at 100 mM, Km: 13 mM Serratia indica

Organism

EC Number Organism UniProt Comment Textmining
6.3.2.12 Serratia indica
-
 IFO 3759
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.3.2.12 ATP + 7,8-dihydropteroate + L-Glu
-
 Serratia indica ADP + phosphate + 7,8-dihydrofolate
-
 ?