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Literature summary extracted from

  • Ueshima, S.; Fang, J.
    Histone H3K9 methyltransferase SETDB1 augments invadopodia formation to promote tumor metastasis (2022), Oncogene, 41, 3370-3380.
    View publication on PubMed

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.366 Mus musculus O88974
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-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.1.1.366 lung adenocarcinoma cell
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 Mus musculus
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2.1.1.366 non-small cell lung cancer cell
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 Mus musculus
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Synonyms

EC Number Synonyms Comment Organism
2.1.1.366 histone H3K9 methyltransferase
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 Mus musculus
2.1.1.366 SETDB1
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 Mus musculus

Expression

EC Number Organism Comment Expression
2.1.1.366 Mus musculus upregulation in non-small cell lung cancer up

General Information

EC Number General Information Comment Organism
2.1.1.366 physiological function SETDB1 strengthens non-small cell lung cancer cell migratory and invasive abilities by promoting invadopodia formation and extracellular matrix degradation. At the molecular level, SETDB1 suppresses the expression of FOXA2, a crucial tumor and metastasis suppressor via coordinated epigenetic mechanisms. SETDB1 not only catalyzes histone H3K9 methylation on FOXA2 genomic locus, but also recruits DNMT3A to regulate DNA methylation on CpG island. Setdb1 is essential for malignant progression and metastasis of murine lung adenocarcinoma Mus musculus