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Literature summary extracted from

  • Chandrasekaran, T.T.; Choudalakis, M.; Bröhm, A.; Weirich, S.; Kouroukli, A.G.; Ammerpohl, O.; Rathert, P.; Bashtrykov, P.; Jeltsch, A.
    SETDB1 activity is globally directed by H3K14 acetylation via its triple tudor domain (2024), Nucleic Acids Res., 52, 13690-13705.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.1.1.366 overexpression using Bac-to-Bac baculovirus expression system, expression in Escherichia coli Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.1.1.366 S-adenosyl-L-methionine + a [histone H3]-N6,N6-dimethyl-L-lysine9 Homo sapiens
-
 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine9
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.366 Homo sapiens Q15047
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.1.1.366
-
 Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.1.1.366 HCT-116 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.1.366 S-adenosyl-L-methionine + a [histone H3]-N6,N6-dimethyl-L-lysine9
-
 Homo sapiens S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine9
-
 ?
2.1.1.366 S-adenosyl-L-methionine + a [histone H3]-N6,N6-dimethyl-L-lysine9 the presence of H3K14ac is required for SETDB1 recruitment via 3TD binding to H3K9me1/2/3-K14ac regions and establishment of H3K9me3 Homo sapiens S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine9
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.1.1.366 SET domain bifurcated histone lysine methyltransferase 1
-
 Homo sapiens
2.1.1.366 SETDB1
-
 Homo sapiens

General Information

EC Number General Information Comment Organism
2.1.1.366 physiological function the enzyme is involved in heterochromatin formation and silencing of repeat elements Homo sapiens