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Literature summary extracted from

  • Rapone, R.; Del Maestro, L.; Bouyioukos, C.; Albini, S.; Cruz-Tapias, P.; Joliot, V.; Cosson, B.; Ait-Si-Ali, S.
    The cytoplasmic fraction of the histone lysine methyltransferase Setdb1 is essential for embryonic stem cells (2023), iScience, 26, 107386.
    View publication on PubMed

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.1.1.366 cytoplasm
-
 Mus musculus 5737
-
2.1.1.366 nucleus
-
 Mus musculus 5634
-

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.366 Mus musculus O88974
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.1.1.366 embryonic stem cell
-
 Mus musculus
-

Synonyms

EC Number Synonyms Comment Organism
2.1.1.366 histone lysine
-
 Mus musculus
2.1.1.366 methyltransferase Setdb1
-
 Mus musculus

General Information

EC Number General Information Comment Organism
2.1.1.366 physiological function the cytoplasmic fraction of the histone lysine methyltransferase Setdb1 is essential for survival of embryonic stem cells. Setdb1 interacts with many RNA-binding proteins and translation regulators such as Trim71. Setdb1 is required for Trim71 complex integrity cSetdb1 regulates the abundance of specific mRNAs, of which Trim71 and hnRNPc targets Mus musculus