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Literature summary extracted from

  • de Groot, A.P.; Nguyen, H.; Pouw, J.S.; Weersing, E.; Dethmers-Ausema, A.; de Haan, G.
    CBX7 inhibitors affect H3K9 methyltransferase-regulated gene repression in leukemic cells (2024), Exp. Hematol., 142, 104691.
    View publication on PubMed

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.366 Homo sapiens Q15047
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Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.1.1.366 leukemia cell
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 Homo sapiens
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2.1.1.366 OCI-AML3 cell
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 Homo sapiens
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Synonyms

EC Number Synonyms Comment Organism
2.1.1.366 H3K9 methyltransferase
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 Homo sapiens
2.1.1.366 SETDB1
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 Homo sapiens

General Information

EC Number General Information Comment Organism
2.1.1.366 metabolism CBX7 inhibition reduces H3K9 methylation levels. CBX7 inhibitors abolish the interaction between CBX7 and H3K9 methyltransferases and block both CBX7-and H3K9 methyltransferase-mediated gene repression Homo sapiens