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Literature summary extracted from

  • Becker, I.; Wang-Eckhardt, L.; Lodder-Gadaczek, J.; Wang, Y.; Gruenewald, A.; Eckhardt, M.
    Mice deficient in the NAAG synthetase II gene Rimkla are impaired in a novel object recognition task (2021), J. Neurochem., 157, 2008-2023.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
6.3.2.42 expressed in HeLa cells Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
6.3.2.42 2 ATP + N-acetyl-L-aspartate + 2 L-glutamate Mus musculus
-
 2 ADP + 2 phosphate + N-acetyl-L-aspartyl-L-glutamyl-L-glutamate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
6.3.2.42 Mus musculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
6.3.2.42 brain stem most abundant Mus musculus
-
6.3.2.42 hippocampus in hippocampus, the enzyme is detectable in neurons expressing parvalbumin Mus musculus
-
6.3.2.42 spinal cord most abundant Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.3.2.42 2 ATP + N-acetyl-L-aspartate + 2 L-glutamate
-
 Mus musculus 2 ADP + 2 phosphate + N-acetyl-L-aspartyl-L-glutamyl-L-glutamate
-
 ?

Subunits

EC Number Subunits Comment Organism
6.3.2.42 ? x * about 50000, SDS-PAGE Mus musculus

Synonyms

EC Number Synonyms Comment Organism
6.3.2.42 NAAG hydrolase glutamate carboxypeptidase II
-
 Mus musculus
6.3.2.42 NAAG synthetase II
-
 Mus musculus
6.3.2.42 NAAGS-II
-
 Mus musculus
6.3.2.42 RIMKLA
-
 Mus musculus

General Information

EC Number General Information Comment Organism
6.3.2.42 malfunction mice deficient in the enzyme gene are impaired in a novel object recognition task Mus musculus
6.3.2.42 physiological function N-acetyl-L-aspartyl-L-glutamate synthesized by the enzyme is directly involved in the memory consolidation underlying the novel object recognition task Mus musculus