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Literature summary extracted from

  • Janke, C.; Rogowski, K.; Wloga, D.; Regnard, C.; Kajava, A.V.; Strub, J.M.; Temurak, N.; van Dijk, J.; Boucher, D.; van Dorsselaer, A.; Suryavanshi, S.; Gaertig, J.; Edde, B.
    Tubulin polyglutamylase enzymes are members of the TTL domain protein family (2005), Science, 308, 1758-1762 .
    View publication on PubMed

Protein Variants

EC Number Protein Variants Comment Organism
6.3.2.62 E422G inactive Tetrahymena thermophila

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
6.3.2.62 cilium
-
 Tetrahymena thermophila 5929
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
6.3.2.61 Mg2+ required Mus musculus
6.3.2.62 Mg2+ required Tetrahymena thermophila

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
6.3.2.61 n ATP + [alpha-tubulin]-L-glutamate + n L-glutamate Mus musculus overall reaction [alpha-tubulin]-(gamma-(poly-alpha-L-glutamyl)-L-glutamyl)-L-glutamate + n ADP + n phosphate
-
 ?
6.3.2.62 n ATP + [beta-tubulin]-L-glutamate + n L-glutamate Tetrahymena thermophila overall reaction. Ttll6Ap is a beta-tubulin-preferring polyglutamylase [beta-tubulin]-(gamma-(poly-alpha-L-glutamyl)-L-glutamyl)-L-glutamate + n ADP + n phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
6.3.2.61 Mus musculus
-
-
-
6.3.2.62 Tetrahymena thermophila
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
6.3.2.61 brain
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.3.2.61 n ATP + [alpha-tubulin]-L-glutamate + n L-glutamate overall reaction Mus musculus [alpha-tubulin]-(gamma-(poly-alpha-L-glutamyl)-L-glutamyl)-L-glutamate + n ADP + n phosphate
-
 ?
6.3.2.62 n ATP + [beta-tubulin]-L-glutamate + n L-glutamate overall reaction. Ttll6Ap is a beta-tubulin-preferring polyglutamylase Tetrahymena thermophila [beta-tubulin]-(gamma-(poly-alpha-L-glutamyl)-L-glutamyl)-L-glutamate + n ADP + n phosphate
-
 ?

Subunits

EC Number Subunits Comment Organism
6.3.2.61 ? x * 49000, calculated from amino acid sequence Mus musculus
6.3.2.62 ? x * 116000, calculated from amino acid sequence Tetrahymena thermophila

Synonyms

EC Number Synonyms Comment Organism
6.3.2.61 neuronal tubulin polyglutamylase
-
 Mus musculus
6.3.2.61 TTLL1 catalytic subunit of neural tubulin polyglutamylase Mus musculus
6.3.2.61 tubulin tyrosine ligase-like protein 1
-
 Mus musculus
6.3.2.62 TTLL6A
-
 Tetrahymena thermophila
6.3.2.62 tubulin tyrosine ligase-like protein 6A
-
 Tetrahymena thermophila