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Literature summary extracted from

  • Ikegami, K.; Sato, S.; Nakamura, K.; Ostrowski, L.; Setou, M.
    Tubulin polyglutamylation is essential for airway ciliary function through the regulation of beating asymmetry (2010), Proc. Natl. Acad. Sci. USA, 107, 10490-10495 .
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
6.3.2.61 n ATP + [tubulin]-L-glutamate + n L-glutamate Mus musculus overall reaction, the enzyme has an initiating activity with a preference for alpha-tubulin, but also shows partial activity on beta-tubulin [tubulin]-(gamma-(poly-alpha-L-glutamyl)-L-glutamyl)-L-glutamate + n ADP + n phosphate
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 ?

Organism

EC Number Organism UniProt Comment Textmining
6.3.2.61 Mus musculus
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-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.3.2.61 n ATP + [tubulin]-L-glutamate + n L-glutamate overall reaction, the enzyme has an initiating activity with a preference for alpha-tubulin, but also shows partial activity on beta-tubulin Mus musculus [tubulin]-(gamma-(poly-alpha-L-glutamyl)-L-glutamyl)-L-glutamate + n ADP + n phosphate
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 ?

Synonyms

EC Number Synonyms Comment Organism
6.3.2.61 TTLL1
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 Mus musculus
6.3.2.61 tubulin tyrosine ligase-like protein 1
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 Mus musculus

General Information

EC Number General Information Comment Organism
6.3.2.61 malfunction along with the loss of axonemal curvature, the axonemes and tracheal epithelial cilia from enzyme knockout mice lose beating asymmetry which results in a reduction of cilia-generated fluid flow in trachea from the knockout mice. The mice display a significant accumulation of mucus in the nasal cavity, and also emit frequent coughing- or sneezing-like noises Mus musculus
6.3.2.61 physiological function enzyme-mediated ubulin polyglutamylation is essential for airway ciliary function through the regulation of beating asymmetry Mus musculus