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Literature summary extracted from

  • Regnard, C.; Fesquet, D.; Janke, C.; Boucher, D.; Desbruyeres, E.; Koulakoff, A.; Insina, C.; Travo, P.; Edde, B.
    Characterisation of PGs1, a subunit of a protein complex co-purifying with tubulin polyglutamylase (2003), J. Cell Sci., 116, 4181-4190 .
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
6.3.2.61 expressed in Escherichia coli BL21(DE3) cells Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
6.3.2.61 n ATP + [alpha-tubulin]-L-glutamate + n L-glutamate Mus musculus overall reaction, higher activity compared to beta-tubulin [alpha-tubulin]-(gamma-(poly-alpha-L-glutamyl)-L-glutamyl)-L-glutamate + n ADP + n phosphate
-
 ?
6.3.2.61 n ATP + [beta-tubulin]-L-glutamate + n L-glutamate Mus musculus overall reaction [beta-tubulin]-(gamma-(poly-alpha-L-glutamyl)-L-glutamyl)-L-glutamate + n ADP + n phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
6.3.2.61 Mus musculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
6.3.2.61 brain highest expression Mus musculus
-
6.3.2.61 colon
-
 Mus musculus
-
6.3.2.61 gut
-
 Mus musculus
-
6.3.2.61 heart
-
 Mus musculus
-
6.3.2.61 kidney
-
 Mus musculus
-
6.3.2.61 lung
-
 Mus musculus
-
6.3.2.61 muscle
-
 Mus musculus
-
6.3.2.61 ovary
-
 Mus musculus
-
6.3.2.61 PCC7-AzaR1 1009 cell
-
 Mus musculus
-
6.3.2.61 small intestine
-
 Mus musculus
-
6.3.2.61 testis
-
 Mus musculus
-
6.3.2.61 thymus lowest expression Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.3.2.61 n ATP + [alpha-tubulin]-L-glutamate + n L-glutamate overall reaction, higher activity compared to beta-tubulin Mus musculus [alpha-tubulin]-(gamma-(poly-alpha-L-glutamyl)-L-glutamyl)-L-glutamate + n ADP + n phosphate
-
 ?
6.3.2.61 n ATP + [beta-tubulin]-L-glutamate + n L-glutamate overall reaction Mus musculus [beta-tubulin]-(gamma-(poly-alpha-L-glutamyl)-L-glutamyl)-L-glutamate + n ADP + n phosphate
-
 ?

Subunits

EC Number Subunits Comment Organism
6.3.2.61 multimer x * 8000 + x * 50000 + x * 32000, SDS-PAGE Mus musculus

Synonyms

EC Number Synonyms Comment Organism
6.3.2.61 PGS1 subunit Mus musculus
6.3.2.61 TPG
-
 Mus musculus
6.3.2.61 tubulin polyglutamylase
-
 Mus musculus