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Literature summary extracted from

  • Van Dijk, J.; Miro, J.; Strub, J.; Lacroix, B.; Van Dorsselaer, A.; Edde, B.; Janke, C.
    Polyglutamylation is a post-translational modification with a broad range of substrates (2008), J. Biol. Chem., 283, 3915-3922.
    View publication on PubMed

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
6.3.2.61 Mg2+ 2.4 mM used in assay conditions Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
6.3.2.61 n ATP + [tubulin]-L-glutamate + n L-glutamate Homo sapiens overall reaction [tubulin]-(gamma-(poly-alpha-L-glutamyl)-L-glutamyl)-L-glutamate + n ADP + n phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
6.3.2.61 Homo sapiens Q14679
-
-
6.3.2.61 Homo sapiens Q6EMB2
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
6.3.2.61 HeLa cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.3.2.61 ATP + acidic nuclear phosphoprotein 32 family, member A + L-glutamate very low activity with isoform TTLL4 Homo sapiens ?
-
 ?
6.3.2.61 ATP + acidic nuclear phosphoprotein 32 family, member A + L-glutamate low activity with isoform TTLL5 Homo sapiens ?
-
 ?
6.3.2.61 ATP + acidic nuclear phosphoprotein 32 family, member B + L-glutamate high activity with isoform TTLL4 Homo sapiens ?
-
 ?
6.3.2.61 ATP + acidic nuclear phosphoprotein 32 family, member B + L-glutamate low activity with isoform TTLL5 Homo sapiens ?
-
 ?
6.3.2.61 ATP + B23 nucleophosmin + L-glutamate highest activity with isoform TTLL4 Homo sapiens ?
-
 ?
6.3.2.61 ATP + B23 nucleophosmin + L-glutamate low activity with isoform TTLL5 Homo sapiens ?
-
 ?
6.3.2.61 ATP + EB1 protein + L-glutamate very low activity with isoform TTLL4 Homo sapiens ?
-
 ?
6.3.2.61 ATP + microtubule + L-glutamate
-
 Homo sapiens ?
-
 ?
6.3.2.61 ATP + microtubule + L-glutamate highest activity with isoform TTLL5 Homo sapiens ?
-
 ?
6.3.2.61 ATP + NF45 protein + L-glutamate very low activity with isoform TTLL4 Homo sapiens ?
-
 ?
6.3.2.61 ATP + NF45 protein + L-glutamate low activity with isoform TTLL5 Homo sapiens ?
-
 ?
6.3.2.61 ATP + NPN2 protein + L-glutamate high activity with isoform TTLL4 Homo sapiens ?
-
 ?
6.3.2.61 ATP + NPN3 protein + L-glutamate very low activity with isoform TTLL4 Homo sapiens ?
-
 ?
6.3.2.61 ATP + nucleosome assembly protein 1-like 1 + L-glutamate
-
 Homo sapiens ?
-
 ?
6.3.2.61 ATP + nucleosome assembly protein 1-like 1 + L-glutamate low activity with isoform TTLL5 Homo sapiens ?
-
 ?
6.3.2.61 ATP + nucleosome assembly protein 1-like 4 + L-glutamate high activity with isoform TTLL4 Homo sapiens ?
-
 ?
6.3.2.61 ATP + nucleosome assembly protein 1-like 4 + L-glutamate
-
 Homo sapiens ?
-
 ?
6.3.2.61 ATP + protein SET + L-glutamate very low activity with isoform TTLL4 Homo sapiens ?
-
 ?
6.3.2.61 ATP + protein SET + L-glutamate high activity with isoform TTLL5 Homo sapiens ?
-
 ?
6.3.2.61 additional information EB3 protein and HMG-B1 are no substrates for isoform TTLL4 Homo sapiens ?
-
 ?
6.3.2.61 n ATP + [tubulin]-L-glutamate + n L-glutamate overall reaction Homo sapiens [tubulin]-(gamma-(poly-alpha-L-glutamyl)-L-glutamyl)-L-glutamate + n ADP + n phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
6.3.2.61 TTLL4 main polyglutamylase enzyme present in HeLa cells Homo sapiens
6.3.2.61 TTLL5
-
 Homo sapiens
6.3.2.61 tubulin-tyrosine ligase-like protein
-
 Homo sapiens