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Literature summary extracted from

  • Zhang, X.; Yu, H.; Zhong, W.; Wang, L.; Li, S.
    Structure-based design, synthesis of novel inhibitors of Mycobacterium tuberculosis FabH as potential anti-tuberculosis agents (2009), Chin. Chem. Lett., 20, 1019-1022 .
No PubMed abstract available

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.1.301 1-(1-bromoheptyl)-4-(4-[[(2,4-difluorophenyl)methyl]amino]phenyl)-1H-pyrrole-2-carboxylic acid compound exhibits strong inhibition on the growth of Mycobacterium tuberculosis H37Rv at 2 and at 4 weeks Mycobacterium tuberculosis
2.3.1.301 1-(1-bromohexyl)-4-(4-[[(3,5-difluorophenyl)methyl]amino]phenyl)-1H-pyrrole-2-carboxylic acid compound exhibits strong inhibition on the growth of Mycobacterium tuberculosis H37Rv at 2 and at 4 weeks Mycobacterium tuberculosis
2.3.1.301 1-(1-bromooctyl)-4-(4-[[(2,5-difluorophenyl)methyl]amino]phenyl)-1H-pyrrole-2-carboxylic acid compound exhibits strong inhibition on the growth of Mycobacterium tuberculosis H37Rv at 2 and at 4 weeks Mycobacterium tuberculosis
2.3.1.301 1-[(3-chlorophenyl)methyl]-4-(4-[[(2,4-difluorophenyl)methyl]amino]phenyl)-1H-pyrrole-2-carboxylic acid compound exhibits strong inhibition on the growth of Mycobacterium tuberculosis H37Rv at 2 and at 4 weeks Mycobacterium tuberculosis
2.3.1.301 1-[(4-chlorophenyl)methyl]-4-(4-[[(2,4-difluorophenyl)methyl]amino]phenyl)-1H-pyrrole-2-carboxylic acid compound exhibits strong inhibition on the growth of Mycobacterium tuberculosis H37Rv at 2 and at 4 weeks Mycobacterium tuberculosis

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.301 Mycobacterium tuberculosis P9WNG3
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2.3.1.301 Mycobacterium tuberculosis ATCC 25618 P9WNG3
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