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Literature summary extracted from

  • Zeng, T.; Han, L.; Pierce, N.; Pfeifer, G.; Szabo, P.
    EHMT2 and SETDB1 protect the maternal pronucleus from 5mC oxidation (2019), Proc. Natl. Acad. Sci. USA, 166, 10834-10841.
    View publication on PubMed

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.366 Mus musculus O88974
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2.1.1.368 Mus musculus Q9Z148
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Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.1.1.366 oocyte
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 Mus musculus
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2.1.1.368 oocyte
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 Mus musculus
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Synonyms

EC Number Synonyms Comment Organism
2.1.1.368 EHMT2
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 Mus musculus

General Information

EC Number General Information Comment Organism
2.1.1.366 physiological function deletion of the catalytic domain of either histone methyltransferases EHMT2 or SETDB1 in growing oocytes leads to significant reduction of global H3K9me2 or H3K9me3 levels, respectively, in the maternal pronucleus. The asymmetry of global 5-methylcytosine (5mC) oxidation is significantly reduced in the zygotes that carry maternal mutation of either the Ehmt2 or Setdb1 genes. The levels of 5-hydroxymethylcytosine, 5-formylcytosine, and 5-carboxylcytosine increase, and 5mC levels decrease in the mutant maternal pronuclei. H3K9me3-rich rings around the nucleolar-like bodies retain 5mC in the maternal mutant zygotes. The maternal pronuclei expand in size in the mutant zygotes and contain a significantly increased number of nucleolar-like bodies compared with normal zygotes Mus musculus
2.1.1.368 physiological function deletion of the catalytic domain of either histone methyltransferases EHMT2 or SETDB1 in growing oocytes leads to significant reduction of global H3K9me2 or H3K9me3 levels, respectively, in the maternal pronucleus. The asymmetry of global 5?methylcytosine (5mC) oxidation is significantly reduced in the zygotes that carry maternal mutation of either the Ehmt2 or Setdb1 genes. The levels of 5-hydroxymethylcytosine, 5-formylcytosine, and 5-carboxylcytosine increase, and 5mC levels decrease in the mutant maternal pronuclei. H3K9me3-rich rings around the nucleolar-like bodies retain 5mC in the maternal mutant zygotes. The maternal pronuclei expand in size in the mutant zygotes and contain a significantly increased number of nucleolar-like bodies compared with normal zygotes Mus musculus