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Literature summary extracted from

  • Jiang, Y.; Loh, Y.E.; Rajarajan, P.; Hirayama, T.; Liao, W.; Kassim, B.S.; Javidfar, B.; Hartley, B.J.; Kleofas, L.; Park, R.B.; Labonte, B.; Ho, S.M.; Chandrasekaran, S.; Do, C.; Ramirez, B.R.; Peter, C.J.; C W, J.T.; Safaie, B.M.; Morishita, H.; Roussos, P.; Nestler, E.J.; Schaefer, A.; Tycko, B.; Brennand, K.
    The methyltransferase SETDB1 regulates a large neuron-specific topological chromatin domain (2017), Nat. Genet., 49, 1239-1250 .
    View publication on PubMedView publication on EuropePMC

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.366 Mus musculus O88974
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Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.1.1.366 brain
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 Mus musculus
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General Information

EC Number General Information Comment Organism
2.1.1.366 physiological function the SETDB1 repressor complex, which involves multiple KRAB zinc finger proteins, shields neuronal genomes from excess CTCF binding and is critically required for structural maintenance of cPcdh topologically associated domain. Neuronal ablation of Setdb1 leads to locus-specific disintegration of megabase-scale chromosomal conformations. The cPcdh topologically associated domain in neurons from mutant mice shows abnormal accumulation of the transcriptional regulator and three-dimensional genome organizer CTCF at cryptic binding sites, in conjunction with DNA cytosine hypomethylation, histone hyperacetylation and upregulated expression. Genes encoding stochastically expressed protocadherins are transcribed by increased numbers of cortical neurons. SETDB1-dependent loop formations bypass 0.2-1 Mb of linear genome and radiate from the cPcdh topologically associated domain fringes toward cis-regulatory sequences within the cPcdh locus Mus musculus