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Literature summary extracted from

  • Kato, M.; Takemoto, K.; Shinkai, Y.
    A somatic role for the histone methyltransferase Setdb1 in endogenous retrovirus silencing (2018), Nat. Commun., 9, 1683 .
    View publication on PubMedView publication on EuropePMC

Application

EC Number Application Comment Organism
2.1.1.366 medicine Setdb1 has a constant role in endogenous retrovirus silencing. Distinctive sets of endogenous retroviruses are reactivated in different types of Setdb1-deficient somatic cells, including the VL30-class of endogenous retroviruses in mouse embryonic fibroblasts. A viral defense response is induced in immortalized Setdb1 knock-out embryonic fibroblasts Mus musculus

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.366 Mus musculus O88974
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Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.1.1.366 embryonic stem cell
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 Mus musculus
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General Information

EC Number General Information Comment Organism
2.1.1.366 physiological function Setdb1 has a constant role in endogenous retrovirus silencing. Distinctive sets of endogenous retroviruses are reactivated in different types of Setdb1-deficient somatic cells, including the VL30-class of endogenous retroviruses in mouse embryonic fibroblasts. A viral defense response is induced in immortalized Setdb1 knock-out embryonic fibroblasts Mus musculus