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Literature summary extracted from

  • Lee, S.; Lee, C.; Hwang, C.Y.; Kim, D.; Han, Y.; Hong, S.N.; Kim, S.H.; Cho, K.H.
    Network inference analysis identifies SETDB1 as a key regulator for reverting colorectal cancer cells into differentiated normal-like cells (2020), Mol. Cancer Res., 18, 118-129.
    View publication on PubMed

Application

EC Number Application Comment Organism
2.1.1.366 medicine SETDB1 depletion effectively converts stem-like colorectal cancer cells into postmitotic cells and restores normal morphology in patient-derived colorectal cancer organoids. SETDB1 depletion recapitulates global gene expression profiles of normal differentiated cells by restoring the transcriptional activity of core transcription factors such as CDX2, ELF3, HNF4G, PPARG, and VDR, on their target genes Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.366 Homo sapiens Q15047
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Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.1.1.366 Caco-2 cell
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 Homo sapiens
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2.1.1.366 HCT-116 cell
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 Homo sapiens
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2.1.1.366 SW-480 cell
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 Homo sapiens
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2.1.1.366 SW-620 cell
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 Homo sapiens
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