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Literature summary extracted from

  • Orouji, E.; Federico, A.; Larribere, L.; Novak, D.; Lipka, D.B.; Assenov, Y.; Sachindra, S.; Hueser, L.; Granados, K.; Gebhardt, C.; Plass, C.; Umansky, V.; Utikal, J.
    Histone methyltransferase SETDB1 contributes to melanoma tumorigenesis and serves as a new potential therapeutic target (2019), Int. J. Cancer, 145, 3462-3477.
    View publication on PubMed

Application

EC Number Application Comment Organism
2.1.1.366 medicine overexpression of SETDB1 contributes to melanoma tumorigenesis. SETDB1 is highly amplified in melanoma cells and in the patient tumors. Increased expression of SETDB1 correlates with SETDB1 amplification and is associated with a more aggressive phenotype in in vitro and in vivo studies. SETDB1 implements its effects via regulation of thrombospondin 1, and the SET-domain of SETDB1 is essential for the maintenance of its tumorigenic activity. Inhibition of SETDB1 reduces cell growth in melanomas resistant to targeted treatments Homo sapiens
2.1.1.366 medicine overexpression of SETDB1 contributes to melanoma tumorigenesis. SETDB1 is highly amplified in melanoma cells. Increased expression of SETDB1 correlates with SETDB1 amplification and is associated with a more aggressive phenotype in in vitro and in vivo studies. SETDB1 implements its effects via regulation of thrombospondin 1, and the SET-domain of SETDB1 is essential for the maintenance of its tumorigenic activity. Inhibition of SETDB1 reduces cell growth in melanomas resistant to targeted treatments Mus musculus

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.366 Homo sapiens Q15047
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2.1.1.366 Mus musculus O88974
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Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.1.1.366 melanoma cell
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 Homo sapiens
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2.1.1.366 melanoma cell
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 Mus musculus
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