Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Mochizuki, K.; Tando, Y.; Sekinaka, T.; Otsuka, K.; Hayashi, Y.; Kobayashi, H.; Kamio, A.; Ito-Matsuoka, Y.; Takehara, A.; Kono, T.; Osumi, N.; Matsui, Y.
    SETDB1 is essential for mouse primordial germ cell fate determination by ensuring BMP signaling (2018), Development, 145, dev164160 .
    View publication on PubMed

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.366 Mus musculus O88974
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.1.1.366 embryo
-
 Mus musculus
-

General Information

EC Number General Information Comment Organism
2.1.1.366 physiological function SETDB1 is an epigenetic regulator of primordial germ cell fate determination. SETDB1-deficient embryos exhibit drastic reduction of nascent primordial germ cells. Dppa2, Otx2 and Utf1 are derepressed whereas mesoderm development-related genes, including BMP4 signaling-related genes, are downregulated by SETDB1 knockdown during primordial germ cell-like cell induction. Binding of SETDB1 is observed at the flanking regions of Dppa2, Otx2 and Utf1 in cell aggregates containing primordial germ cell-like cell induction, and trimethylation of lysine 9 of histone H3 is reduced by SETDB1 knockdown at those regions Mus musculus