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Literature summary extracted from

  • Fatima, A.; Irmak, D.; Noormohammadi, A.; Rinschen, M.M.; Das, A.; Leidecker, O.; Schindler, C.; Sanchez-Gaya, V.; Wagle, P.; Pokrzywa, W.; Hoppe, T.; Rada-Iglesias, A.; Vilchez, D.
    The ubiquitin-conjugating enzyme UBE2K determines neurogenic potential through histone H3 in human embryonic stem cells (2020), Commun. Biol., 3, 262 .
    View publication on PubMedView publication on EuropePMC

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.366 Homo sapiens Q15047
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Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.1.1.366 embryo embryonic stem cell Homo sapiens
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2.1.1.366 embryonic stem cell
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 Homo sapiens
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General Information

EC Number General Information Comment Organism
2.1.1.366 physiological function embryonic stem cells exhibit high expression of the ubiquitin-conjugating enzyme UBE2K. Loss of UBE2K upregulates the trimethyltransferase SETDB1, resulting in H3K9 trimethylation and repression of neurogenic genes during differentiation Homo sapiens