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Literature summary extracted from

  • Price, A.J.; Manjegowda, M.C.; Kain, J.; Anandh, S.; Bochkis, I.M.
    Hdac3, Setdb1, and Kap1 mark H3K9me3/H3K14ac bivalent regions in young and aged liver (2020), Aging Cell, 19, e13092.
    View publication on PubMed

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.366 Mus musculus O88974
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Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.1.1.366 liver
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 Mus musculus
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General Information

EC Number General Information Comment Organism
2.1.1.366 physiological function bivalend combinantion, dually marked histones H3K9me3/H3K14ac modification in the liver, is significantly decreased in old hepatocytes. A correlation between H3K9me3/H3K14ac bulk bivalent genomic regions and dually marked single nucleosomes is suggested. Histone H3K9 deacetylase Hdac3, as well as H3K9 methyltransferase Setdb1, found in complex Kap1, occupy both bulk and single nucleosome bivalent regions in both young and old livers, correlating to presence of H3K9me3. Expression of genes associated with bivalent regions in young liver, including those regulating cholesterol secretion and triglyceride synthesis, is upregulated in old liver once the bivalency is lost Mus musculus