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Literature summary extracted from

  • van Dijk, J.; Rogowski, K.; Miro, J.; Lacroix, B.; Edde, B.; Janke, C.
    A targeted multienzyme mechanism for selective microtubule polyglutamylation (2007), Mol. Cell, 26, 437-448 .
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
6.3.2.61 expressed in HeLa cells Mus musculus
6.3.2.62 overexpression in HeLa cells Mus musculus

Protein Variants

EC Number Protein Variants Comment Organism
6.3.2.61 additional information TTLL6_N705 is a stable and enzymatically active truncated protein version. Unlike the full-length enzyme TTLL6, the truncated protein does not localize to cilia Mus musculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
6.3.2.61 cilium
-
 Mus musculus 5929
-
6.3.2.61 flagellar basal body
-
 Mus musculus
-
-

Organism

EC Number Organism UniProt Comment Textmining
6.3.2.61 Mus musculus Q91V51
-
-
6.3.2.61 Mus musculus Q8CHB8
-
-
6.3.2.61 Mus musculus A4Q9E8
-
-
6.3.2.61 Mus musculus A4Q9F4
-
-
6.3.2.61 Mus musculus A4Q9F6
-
-
6.3.2.62 Mus musculus A4Q9F0
-
-
6.3.2.62 Mus musculus Q80UG8
-
-
6.3.2.62 Tetrahymena thermophila Q23MT7
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
6.3.2.61
-
 Mus musculus
6.3.2.62
-
 Mus musculus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
6.3.2.61 brain high expression Mus musculus
-
6.3.2.61 MDCK cell TTLL5 localizes to both basal bodies and cilia Mus musculus
-
6.3.2.61 MDCK cell TTLL6 localizes to both basal bodies and cilia Mus musculus
-
6.3.2.61 neuron
-
 Mus musculus
-
6.3.2.61 testis high expression Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.3.2.61 additional information TTLL1 is an alpha-tubulin preferring polyglutamylase. TTLL1 is solely active as part of a multiprotein complex, that can potentially contain exchangeable regulatory subunits Mus musculus ?
-
 ?
6.3.2.61 n ATP + [alpha-tubulin]-(alpha-L-glutamyl-gamma-L-glutamyl)-L-glutamate + n L-glutamate no initiating activity, high elongation activity. The enzyme modifies both alpha- and beta-tubulin and shows a preference towards alpha-tubulin Mus musculus [alpha-tubulin]-(gamma-(poly-alpha-L-glutamyl)-L-glutamyl)-L-glutamate + n ADP + n phosphate
-
 ?
6.3.2.61 n ATP + [alpha-tubulin]-L-glutamate + n L-glutamate high initiating activity, low elongation activity. High activity with alpha-tubulin, low activity with beta-tubulin. Upon overexpression in HeLa cells, TTLL5 modifies mostly alpha-tubulin Mus musculus [alpha-tubulin]-(gamma-(poly-alpha-L-glutamyl)-L-glutamyl)-L-glutamate + n ADP + n phosphate
-
 ?
6.3.2.61 n ATP + [alpha-tubulin]-L-glutamate + n L-glutamate low initiating activity, high elongation activity. High activity with alpha-tubulin, low activity with beta-tubulin. Upon overexpression in HeLa cells, TTLL5 modifies mostly alpha-tubulin Mus musculus [alpha-tubulin]-(gamma-(poly-alpha-L-glutamyl)-L-glutamyl)-L-glutamate + n ADP + n phosphate
-
 ?
6.3.2.61 n ATP + [alpha-tubulin]-L-glutamate + n L-glutamate low initiating activity, high elongation activity. The enzyme modifies both alpha- and beta-tubulin and shows a preference towards alpha-tubulin Mus musculus [alpha-tubulin]-(gamma-(poly-alpha-L-glutamyl)-L-glutamyl)-L-glutamate + n ADP + n phosphate
-
 ?
6.3.2.61 n ATP + [beta-tubulin]-(alpha-L-glutamyl-gamma-L-glutamyl)-L-glutamate + n L-glutamate no initiating activity, high elongation activity. The enzyme modifies both alpha- and beta-tubulin and shows a preference towards alpha-tubulin Mus musculus [beta-tubulin]-(gamma-(poly-alpha-L-glutamyl)-L-glutamyl)-L-glutamate + n ADP + n phosphate
-
 ?
6.3.2.61 n ATP + [beta-tubulin]-L-glutamate + n L-glutamate high initiating activity, low elongation activity. High activity with alpha-tubulin, low activity with beta-tubulin Mus musculus [beta-tubulin]-(gamma-(poly-alpha-L-glutamyl)-L-glutamyl)-L-glutamate + n ADP + n phosphate
-
 ?
6.3.2.61 n ATP + [beta-tubulin]-L-glutamate + n L-glutamate low initiating activity, high elongation activity. High activity with alpha-tubulin, low activity with beta-tubulin Mus musculus [beta-tubulin]-(gamma-(poly-alpha-L-glutamyl)-L-glutamyl)-L-glutamate + n ADP + n phosphate
-
 ?
6.3.2.61 n ATP + [beta-tubulin]-L-glutamate + n L-glutamate low initiating activity, high elongation activity. The enzyme modifies both alpha- and beta-tubulin and shows a preference towards alpha-tubulin Mus musculus [beta-tubulin]-(gamma-(poly-alpha-L-glutamyl)-L-glutamyl)-L-glutamate + n ADP + n phosphate
-
 ?
6.3.2.62 ATP + [alpha-tubulin]-L-glutamate + L-glutamate high initiating activity, no elongation activity. The enzyme modifies both alpha- and beta-tubulin and shows a preference towards beta-tubulin Mus musculus [alpha-tubulin]-(gamma-L-glutamyl)-L-glutamate + ADP + phosphate
-
 ?
6.3.2.62 ATP + [beta-tubulin]-L-glutamate + L-glutamate high initiating activity, no elongation activity. The enzyme modifies both alpha- and beta-tubulin and shows a preference towards beta-tubulin Mus musculus [beta-tubulin]-(gamma-L-glutamyl)-L-glutamate + ADP + phosphate
-
 ?
6.3.2.62 n ATP + [alpha-tubulin]-(alpha-L-glutamyl-gamma-L-glutamyl)-L-glutamate + n L-glutamate no initiating activity, high elongation activity. The enzyme modifies both alpha- and beta-tubulin and shows a preference towards beta-tubulin Tetrahymena thermophila [alpha-tubulin]-(gamma-(poly-alpha-L-glutamyl)-L-glutamyl)-L-glutamate + n ADP + n phosphate
-
 ?
6.3.2.62 n ATP + [alpha-tubulin]-L-glutamate + n L-glutamate high initiating activity, low elongation activity. The enzyme modifies both alpha- and beta-tubulin and shows a preference towards beta-tubulin Mus musculus [alpha-tubulin]-(gamma-(poly-alpha-L-glutamyl)-L-glutamyl)-L-glutamate + n ADP + n phosphate
-
 ?
6.3.2.62 n ATP + [beta-tubulin]-(alpha-L-glutamyl-gamma-L-glutamyl)-L-glutamate + n L-glutamate no initiating activity, high elongation activity. The enzyme modifies both alpha- and beta-tubulin and shows a preference towards beta-tubulin Tetrahymena thermophila [beta-tubulin]-(gamma-(poly-alpha-L-glutamyl)-L-glutamyl)-L-glutamate + n ADP + n phosphate
-
 ?
6.3.2.62 n ATP + [beta-tubulin]-L-glutamate + n L-glutamate high initiating activity, low elongation activity. The enzyme modifies both alpha- and beta-tubulin and shows a preference towards beta-tubulin Mus musculus [beta-tubulin]-(gamma-(poly-alpha-L-glutamyl)-L-glutamyl)-L-glutamate + n ADP + n phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
6.3.2.61 TTLL1 isoform Mus musculus
6.3.2.61 TTLL11 isoform Mus musculus
6.3.2.61 TTLL13 isoform Mus musculus
6.3.2.61 TTLL5 isoform Mus musculus
6.3.2.61 ttll6 isoform Mus musculus
6.3.2.61 tubulin polyglutamylase
-
 Mus musculus
6.3.2.62 elongating polyglutamylase
-
 Tetrahymena thermophila
6.3.2.62 TTLL4
-
 Mus musculus
6.3.2.62 TTLL7
-
 Mus musculus
6.3.2.62 TtTtll6Ap
-
 Tetrahymena thermophila