Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Doerfel, M.J.; Lyon, G.J.
    The biological functions of Naa10 - From amino-terminal acetylation to human disease (2015), Gene, 567, 103-131.
    View publication on PubMedView publication on EuropePMC

Application

EC Number Application Comment Organism
2.3.1.255 medicine the enzyme is associated with Ogden syndrome Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.3.1.255 cytoplasm
-
 Homo sapiens 5737
-
2.3.1.255 nucleus
-
 Homo sapiens 5634
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.3.1.255 26000
-
-
 Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.255 Homo sapiens P41227
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.255 HeLa cell
-
 Homo sapiens
-
2.3.1.255 HT-1080 cell
-
 Homo sapiens
-
2.3.1.255 U2OS cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.255 additional information Naa10 undergoes autoacetylation at lysine K136 Homo sapiens ?
-
 ?

Subunits

EC Number Subunits Comment Organism
2.3.1.255 ? x * 26000, calculated from amino acid sequence Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
2.3.1.255 ARD1
-
 Homo sapiens
2.3.1.255 arrest-defective protein 1 homologue
-
 Homo sapiens
2.3.1.255 DXS707
-
 Homo sapiens
2.3.1.255 NAA10 gene name, catalytic subunit of NatA Homo sapiens
2.3.1.255 Nalpha-acetyltransferase 10
-
 Homo sapiens
2.3.1.255 NatA
-
 Homo sapiens
2.3.1.255 TE2
-
 Homo sapiens

Expression

EC Number Organism Comment Expression
2.3.1.255 Homo sapiens the expression of Naa10 increases during neuronal dendritic development of cerebellar Purkinje cells up

General Information

EC Number General Information Comment Organism
2.3.1.255 malfunction knockdown of Naa10 in HeLa cells leads to apoptosis and sensitizes cells for daunorubicin-induced apoptosis Homo sapiens
2.3.1.255 metabolism Naa10 activates and/or amplifies the transcriptional activity of beta-catenin/TCF transcriptional activity thereby stimulating cyclin D1 and c-Myc expression leading to inhibition of p21WAF1/CIP1 and promoting the G1/S cell cycle transition. Naa10 is essential for the activation of caspase-2/-3/-7 and -9 in HeLa cells after doxorubicin stimulation Homo sapiens