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Literature summary for 7.6.2.8 extracted from

  • Gopinath, K.; Venclovas, A.; Ioerger, T.; Sacchettini, J.; McKinney, J.; Mizrahi, V.; Warner, D.
    A vitamin B12 transporter in Mycobacterium tuberculosis (2013), Open Biology, 3, 120175.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 7.6.2.8

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
 Mycobacterium tuberculosis 16020
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + H2O + vitamin B12/out Mycobacterium tuberculosis
-
 ADP + phosphate + vitamin B12/in
-
 ?

Organism

Organism UniProt Comment Textmining
Mycobacterium tuberculosis
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O + vitamin B12/out
-
 Mycobacterium tuberculosis ADP + phosphate + vitamin B12/in
-
 ?

Synonyms

Synonyms Comment Organism
BtuCD
-
 Mycobacterium tuberculosis
Rv1819c
-
 Mycobacterium tuberculosis
vitamin B12 transporter
-
 Mycobacterium tuberculosis

General Information

General Information Comment Organism
malfunction gene disruption eliminates the ability of Mycobacterium tuberculosis to use exogenous vitamin B12 in vitro Mycobacterium tuberculosis
physiological function the enzyme is required for the assimilation of exogenous vitamin B12 to enable methylmalonyl-CoA pathway function and is essential for corrinoid transport Mycobacterium tuberculosis