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Literature summary for 7.6.2.4 extracted from

  • Nyathi, Y.; De Marcos Lousa, C.; van Roermund, C.W.; Wanders, R.J.; Johnson, B.; Baldwin, S.A.; Theodoulou, F.L.; Baker, A.
    The Arabidopsis peroxisomal ABC transporter, comatose, complements the Saccharomyces cerevisiae pxa1 pxa2Delta mutant for metabolism of long-chain fatty acids and exhibits fatty acyl-CoA-stimulated ATPase activity (2010), J. Biol. Chem., 285, 29892-29902.
    View publication on PubMedView publication on EuropePMC
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Protein Variants

Protein Variants Comment Organism
K487A mutation in Walker A motif, no beta-oxidation activity Arabidopsis thaliana
additional information upon expression in Saccharomyces cerevisiae, CTS is correctly targeted to yeast peroxisomes, assembled into the membrane with its nucleotide binding domains in the cytosol, and exhibits basal ATPase activity that is sensitive to aluminum fluoride and abrogated by mutation of a conserved Walker A motif lysine residue. CTS rescues the oleate growth phenotype of the pxa1 pxa2 deletion mutant, and restores beta-oxidation of fatty acids with a range of chain lengths and varying degrees of desaturation. When expressed in yeast peroxisomal membranes, the basal ATPase activity of CTS can be stimulated by fatty acyl-CoAs but not by fatty acids Arabidopsis thaliana

Inhibitors

Inhibitors Comment Organism Structure
aluminium fluoride strong inhibition Arabidopsis thaliana

Localization

Localization Comment Organism GeneOntology No. Textmining
peroxisome upon expression in Saccharomyces cerevisiae, CTS is correctly targeted to yeast peroxisomes, and assembled into the membrane with its nucleotide binding domains in the cytosol Arabidopsis thaliana 5777
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Organism

Organism UniProt Comment Textmining
Arabidopsis thaliana
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Synonyms

Synonyms Comment Organism
comatose
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 Arabidopsis thaliana
CTS
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 Arabidopsis thaliana