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Literature summary for 7.6.2.4 extracted from

  • Netik, A.; Forss-Petter, S.; Holzinger, A.; Molzer, B.; Unterrainer, G.; Berger, J.
    Adrenoleukodystrophy-related protein can compensate functionally for adrenoleukodystrophy protein deficiency (X-ALD): implications for therapy (1999), Hum. Mol. Genet., 8, 907-913.
    View publication on PubMed

Application

Application Comment Organism
medicine a correction of the biochemical defect of X-linked adrenoleukodystrophy could be possible by drug-induced overexpression or ectopic expression of adrenoleukodystrophy-related protein Mus musculus
medicine a correction of the biochemical defect of X-linked adrenoleukodystrophy could be possible by drug-induced overexpression or ectopic expression of adrenoleukodystrophy-related protein Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
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Mus musculus
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-
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Source Tissue

Source Tissue Comment Organism Textmining
skin fibroblast SV40-transformed, from a patient with X-linked adrenoleukodystrophy missense mutation A626T Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O + fatty acyl CoA/cis
-
Mus musculus ADP + phosphate + fatty acyl CoA/trans
-
?
ATP + H2O + fatty acyl CoA/cis
-
Homo sapiens ADP + phosphate + fatty acyl CoA/trans
-
?