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Literature summary for 7.6.2.15 extracted from
- Thiamin transport in Escherichia coli The mechanism of inhibition by the sulfhydryl-specific modifier N-ethylmaleimide (2002), Biochim. Biophys. Acta, 1564, 421-428 .
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| N-ethylmaleimide | noncompetitive inhibition | Escherichia coli |  |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0000152 | - |
(thiazole-2-)thiamine-[thiamine-binding protein][side 1] | at 37°C, pH not specified in the publication | Escherichia coli |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + H2O + thiamine-[thiamine-binding protein][side 1] | Escherichia coli | - |
ADP + phosphate + thiamine[side 2] + [thiamine-binding protein][side 1] | - |
? | |
| ATP + H2O + thiamine-[thiamine-binding protein][side 1] | Escherichia coli KG33 | - |
ADP + phosphate + thiamine[side 2] + [thiamine-binding protein][side 1] | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Escherichia coli | - |
- |
- |
| Escherichia coli KG33 | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + H2O + (thiazole-2-)thiamine-[thiamine-binding protein][side 1] | - |
Escherichia coli | ADP + phosphate + (thiazole-2-)thiamine[side 2] + [thiamine-binding protein][side 1] | - |
? | |
| ATP + H2O + (thiazole-2-)thiamine-[thiamine-binding protein][side 1] | - |
Escherichia coli KG33 | ADP + phosphate + (thiazole-2-)thiamine[side 2] + [thiamine-binding protein][side 1] | - |
? | |
| ATP + H2O + thiamine-[thiamine-binding protein][side 1] | - |
Escherichia coli | ADP + phosphate + thiamine[side 2] + [thiamine-binding protein][side 1] | - |
? | |
| ATP + H2O + thiamine-[thiamine-binding protein][side 1] | - |
Escherichia coli KG33 | ADP + phosphate + thiamine[side 2] + [thiamine-binding protein][side 1] | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| thiamine transporting ATPase | - |
Escherichia coli |
| thiBPQ | - |
Escherichia coli |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.8 | - |
N-ethylmaleimide | at 37°C, pH not specified in the publication | Escherichia coli | |
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