Application | Comment | Organism |
---|---|---|
medicine | spontaneous loss of lipid asymmetry, not corrected by aminophospholipid translocase activity, is the mechanism for ribavirin-induced phosphatidylserine exposure that may contribute to ribavirin-induced anemia | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
ribavirin | prolonged treatment of erythrocytes with ribavirin results in surface exposure of phosphatidylserine, mainly caused by inactivation of the aminophospholipid translocase. Inactivation is due to severe ATP depletion | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
erythrocyte | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
fluorescent labeled phosphatidylserine/outer leaflet + ATP + H2O | enzyme specifically transports phosphatidylserine from the outer to the inner leaflet of the plasma membrane | Homo sapiens | fluorescent labeled phosphatidylserine/inner leaflet + ADP + phosphate | - |
? |