Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | zVAD, a pancaspase inhibitor, and TcdB, a caspase 3 inductor, induces membrane flip-flop in H9c2 cells, overview | Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
plasma membrane | - |
Rattus norvegicus | 5886 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | - |
Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + H2O + phosphatidylserine/in | Rattus norvegicus | leading to reversible exposure on in the outer plasma membrane leaflet on the cell surface of cardiomyocytes by a flip-flop mechanism | ADP + phosphate + phosphatidylserine/out | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
cardiomyoblast | - |
Rattus norvegicus | - |
cardiomyocyte | adult ventricular | Rattus norvegicus | - |
H9c2 cell | neonatal rat cardiomyoblasts | Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + H2O + phosphatidylserine/in | - |
Rattus norvegicus | ADP + phosphate + phosphatidylserine/out | - |
? | |
ATP + H2O + phosphatidylserine/in | leading to reversible exposure on in the outer plasma membrane leaflet on the cell surface of cardiomyocytes by a flip-flop mechanism | Rattus norvegicus | ADP + phosphate + phosphatidylserine/out | - |
? |
Synonyms | Comment | Organism |
---|---|---|
flippase | - |
Rattus norvegicus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Rattus norvegicus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7 | - |
assay at | Rattus norvegicus |
General Information | Comment | Organism |
---|---|---|
physiological function | flippase selectively transports phosphatidylserine from the outer to the inner plasma membrane layer and thereby maintains transbilayer phospholipid asymmetry. Possible role for Rho 34 and downstream effector Rho-associated kinase in the process of reversible phosphatidylserine exposure, involving the flippase and apoptosis in cardiomyocytes. Regulation of Rho-ROCK signaling and effect of inhibition of Rho-ROCK signaling on flippase activity, overview. Inhibition of Rho-ROCK signaling, by Y27632 or H1152, induces apoptotic and non-apoptotic phosphatidylserine exposure in cardiomyocytes via inhibition of flippase | Rattus norvegicus |