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Literature summary for 7.6.2.1 extracted from

  • Masuda, M.; Nakai, E.; Mizutani, T.
    Study of oxidized lipids as endogenous substrates of P-gp (ABCB1) (2008), Drug Metab. Lett., 2, 238-244.
    View publication on PubMed
Search for more literature for 7.6.2.1

Inhibitors

Inhibitors Comment Organism Structure
orthovanadate
-
 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
 Homo sapiens 16020
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O + asolectin/out
-
 Homo sapiens ADP + phosphate + asolectin/in
-
 ?
ATP + H2O + galactocerebroside/out
-
 Homo sapiens ADP + phosphate + galactocerebroside/in
-
 ?
ATP + H2O + lactocerebroside/out
-
 Homo sapiens ADP + phosphate + lactocerebroside/in
-
 ?
ATP + H2O + sphingomyelin/out
-
 Homo sapiens ADP + phosphate + sphingomyelin/in
-
 ?
ATP + H2O + verapamil/out highest activity Homo sapiens ADP + phosphate + verapamil/in
-
 ?
additional information phosphatidylcholine, phosphatidylethanolamine, phophatidylserine, triglyceride, and cholesterol are no substrates of P-glycoprotein, ethyl acetate extracts from mouse brain homogenate exhibit weak substrate activity of P-glycoprotein Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
ABCB1
-
 Homo sapiens
P-glycoprotein
-
 Homo sapiens
P-gp
-
 Homo sapiens